Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

Despite advances in precision medicine, the clinical prospects for patients with ovarian and uterine cancers have not substantially improved. Here, we analyzed genome-scale CRISPR/Cas9 loss-of-function screens across 851 human cancer cell lines and found that frequent overexpression of SLC34A2 – enc...

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Detalles Bibliográficos
Autores principales: Bondeson, Daniel P, Paolella, Brenton R, Asfaw, Adhana, Rothberg, Michael V, Skipper, Thomas A, Langan, Carly, Mesa, Gabriel, Gonzalez, Alfredo, Surface, Lauren E, Ito, Kentaro, Kazachkova, Mariya, Colgan, William N, Warren, Allison, Dempster, Josh M, Krill-Burger, John M, Ericsson, Maria, Tang, Andrew A, Fung, Iris, Chambers, Emily S, Abdusamad, Mai, Dumont, Nancy, Doench, John G, Piccioni, Federica, Root, David E, Boehm, Jesse, Hahn, William C, Mannstadt, Michael, McFarland, James M, Vazquez, Francisca, Golub, Todd R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246846/
https://www.ncbi.nlm.nih.gov/pubmed/35437317
http://dx.doi.org/10.1038/s43018-022-00360-7

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