A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice

We have previously reported that amodiaquine, a compound that binds to the ligand-binding domain of a nuclear receptor Nurr1, attenuates inflammatory responses and neurological deficits after intracerebral hemorrhage (ICH) in mice. 1,1-Bis(3′-indolyl)-1-(p-chlorophenyl)methane (C-DIM12) is another N...

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Detalles Bibliográficos
Autores principales: Kinoshita, Keita, Yoshimizu, Ayaka, Ichihara, Yusei, Ushida, Keisuke, Kotani, Shunsuke, Kurauchi, Yuki, Seki, Takahiro, Katsuki, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246855/
https://www.ncbi.nlm.nih.gov/pubmed/35773404
http://dx.doi.org/10.1038/s41598-022-15178-7

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