Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state

PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification of PPM1D are found across numerous cancer types. GSK2830371 is a potent and selective allosteric inhibitor of PPM1D, but its mechanism of bi...

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Detalles Bibliográficos
Autores principales: Miller, Peter G., Sathappa, Murugappan, Moroco, Jamie A., Jiang, Wei, Qian, Yue, Iqbal, Sumaiya, Guo, Qi, Giacomelli, Andrew O., Shaw, Subrata, Vernier, Camille, Bajrami, Besnik, Yang, Xiaoping, Raffier, Cerise, Sperling, Adam S., Gibson, Christopher J., Kahn, Josephine, Jin, Cyrus, Ranaghan, Matthew, Caliman, Alisha, Brousseau, Merissa, Fischer, Eric S., Lintner, Robert, Piccioni, Federica, Campbell, Arthur J., Root, David E., Garvie, Colin W., Ebert, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246869/
https://www.ncbi.nlm.nih.gov/pubmed/35773251
http://dx.doi.org/10.1038/s41467-022-30463-9

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