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A phase 1b study of andecaliximab in combination with S-1 plus platinum in Japanese patients with gastric adenocarcinoma

Andecaliximab (ADX) is a monoclonal antibody that inhibits matrix metalloproteinase 9 (MMP9), an extracellular enzyme involved in matrix remodeling, tumor growth, and metastasis. In preclinical models, MMP9 inhibitors have been shown to enhance the cytotoxic effects of chemotherapeutic agents and to...

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Detalles Bibliográficos
Autores principales:	Ooki, Akira, Satoh, Taroh, Muro, Kei, Takashima, Atsuo, Kadowaki, Shigenori, Sakai, Daisuke, Ichimura, Takashi, Mitani, Seiichiro, Kudo, Toshihiro, Chin, Keisho, Kitano, Shigehisa, Thai, Dung, Zavodovskaya, Marianna, Liu, JieJane, Boku, Narikazu, Yamaguchi, Kensei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246925/ https://www.ncbi.nlm.nih.gov/pubmed/35773363 http://dx.doi.org/10.1038/s41598-022-13801-1

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