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Retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve
The study investigated clinical features of sellar and suprasellar tumors with optic nerve bending. Twenty-five patients (13 men/12 women; age, 59.0 ± 12.9 years) with optic nerve bending in one eye who underwent tumor resection for sellar and suprasellar tumors were included. The other eye, without...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246971/ https://www.ncbi.nlm.nih.gov/pubmed/35773336 http://dx.doi.org/10.1038/s41598-022-15381-6 |
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author | Shinohara, Yoichiro Todokoro, Daisuke Yamaguchi, Rei Tosaka, Masahiko Yoshimoto, Yuhei Akiyama, Hideo |
author_facet | Shinohara, Yoichiro Todokoro, Daisuke Yamaguchi, Rei Tosaka, Masahiko Yoshimoto, Yuhei Akiyama, Hideo |
author_sort | Shinohara, Yoichiro |
collection | PubMed |
description | The study investigated clinical features of sellar and suprasellar tumors with optic nerve bending. Twenty-five patients (13 men/12 women; age, 59.0 ± 12.9 years) with optic nerve bending in one eye who underwent tumor resection for sellar and suprasellar tumors were included. The other eye, without optic nerve bending, was the control. The pre- and postoperative best-corrected visual acuity (BCVA) and ganglion cell layer (GCL) + inner plexiform layer (IPL) thickness were studied retrospectively using optical coherence tomography. Preoperative BCVA in the eye with optic nerve bending was significantly poor and improved significantly after tumor resection. Eyes with optic nerve bending had significantly less GCL + IPL thickness on the temporal side than eyes without optic nerve bending. Preoperative GCL + IPL thickness of the entire macula was reduced in eyes with optic nerve bending and poor postoperative BCVA compared to those with good postoperative BCVA. There was no significant difference in GCL + IPL thickness of eyes with optic nerve bending before and after tumor resection. Optic nerve bending caused by sellar and suprasellar tumors resulted in visual impairment and decreased retinal ganglion cells. Eyes with optic nerve bending and severely reduced GCL + IPL thickness may have less BCVA improvement after tumor resection. |
format | Online Article Text |
id | pubmed-9246971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-92469712022-07-02 Retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve Shinohara, Yoichiro Todokoro, Daisuke Yamaguchi, Rei Tosaka, Masahiko Yoshimoto, Yuhei Akiyama, Hideo Sci Rep Article The study investigated clinical features of sellar and suprasellar tumors with optic nerve bending. Twenty-five patients (13 men/12 women; age, 59.0 ± 12.9 years) with optic nerve bending in one eye who underwent tumor resection for sellar and suprasellar tumors were included. The other eye, without optic nerve bending, was the control. The pre- and postoperative best-corrected visual acuity (BCVA) and ganglion cell layer (GCL) + inner plexiform layer (IPL) thickness were studied retrospectively using optical coherence tomography. Preoperative BCVA in the eye with optic nerve bending was significantly poor and improved significantly after tumor resection. Eyes with optic nerve bending had significantly less GCL + IPL thickness on the temporal side than eyes without optic nerve bending. Preoperative GCL + IPL thickness of the entire macula was reduced in eyes with optic nerve bending and poor postoperative BCVA compared to those with good postoperative BCVA. There was no significant difference in GCL + IPL thickness of eyes with optic nerve bending before and after tumor resection. Optic nerve bending caused by sellar and suprasellar tumors resulted in visual impairment and decreased retinal ganglion cells. Eyes with optic nerve bending and severely reduced GCL + IPL thickness may have less BCVA improvement after tumor resection. Nature Publishing Group UK 2022-06-30 /pmc/articles/PMC9246971/ /pubmed/35773336 http://dx.doi.org/10.1038/s41598-022-15381-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Shinohara, Yoichiro Todokoro, Daisuke Yamaguchi, Rei Tosaka, Masahiko Yoshimoto, Yuhei Akiyama, Hideo Retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve |
title | Retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve |
title_full | Retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve |
title_fullStr | Retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve |
title_full_unstemmed | Retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve |
title_short | Retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve |
title_sort | retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246971/ https://www.ncbi.nlm.nih.gov/pubmed/35773336 http://dx.doi.org/10.1038/s41598-022-15381-6 |
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