Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers

PURPOSE: Multidrug resistance protein 1 (MDR1) is located at the interface between two syncytiotrophoblast layers in rodent placenta, and may influence fetal drug distribution. Here, we quantitatively compare the functional impact per single MDR1 molecule of MDR1 at the placental barrier and blood-b...

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Detalles Bibliográficos
Autores principales: Fujita, Arimi, Noguchi, Saki, Hamada, Rika, Inoue, Satoko, Shimada, Tsutomu, Katakura, Satomi, Maruyama, Tetsuo, Sai, Yoshimichi, Nishimura, Tomohiro, Tomi, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246986/
https://www.ncbi.nlm.nih.gov/pubmed/35083640
http://dx.doi.org/10.1007/s11095-022-03165-6

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