Cargando…
Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
Virtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively st...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247055/ https://www.ncbi.nlm.nih.gov/pubmed/35773327 http://dx.doi.org/10.1038/s42003-022-03600-9 |
_version_ | 1784739066437173248 |
---|---|
author | Jarabo, Patricia Barredo, Celia G. de Pablo, Carmen Casas-Tinto, Sergio Martin, Francisco A. |
author_facet | Jarabo, Patricia Barredo, Celia G. de Pablo, Carmen Casas-Tinto, Sergio Martin, Francisco A. |
author_sort | Jarabo, Patricia |
collection | PubMed |
description | Virtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively studied on cancer. Still, mechanisms underlying these alterations, and how they favor tumor development remain largely unknown. Here, we show that glioblastoma-induced neurodegeneration also causes circadian alterations in Drosophila. Preventing neurodegeneration in all neurons by genetic means reestablishes normal biological rhythms. Interestingly, in early stages of tumor development, the central pacemaker lengthens its period, whereas in later stages this is severely disrupted. The re-adjustment of the external light:dark period to longer glioblastoma-induced internal rhythms delays glioblastoma progression and ameliorates associated deleterious effects, even after the tumor onset. |
format | Online Article Text |
id | pubmed-9247055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-92470552022-07-02 Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila Jarabo, Patricia Barredo, Celia G. de Pablo, Carmen Casas-Tinto, Sergio Martin, Francisco A. Commun Biol Article Virtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively studied on cancer. Still, mechanisms underlying these alterations, and how they favor tumor development remain largely unknown. Here, we show that glioblastoma-induced neurodegeneration also causes circadian alterations in Drosophila. Preventing neurodegeneration in all neurons by genetic means reestablishes normal biological rhythms. Interestingly, in early stages of tumor development, the central pacemaker lengthens its period, whereas in later stages this is severely disrupted. The re-adjustment of the external light:dark period to longer glioblastoma-induced internal rhythms delays glioblastoma progression and ameliorates associated deleterious effects, even after the tumor onset. Nature Publishing Group UK 2022-06-30 /pmc/articles/PMC9247055/ /pubmed/35773327 http://dx.doi.org/10.1038/s42003-022-03600-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Jarabo, Patricia Barredo, Celia G. de Pablo, Carmen Casas-Tinto, Sergio Martin, Francisco A. Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila |
title | Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila |
title_full | Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila |
title_fullStr | Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila |
title_full_unstemmed | Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila |
title_short | Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila |
title_sort | alignment between glioblastoma internal clock and environmental cues ameliorates survival in drosophila |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247055/ https://www.ncbi.nlm.nih.gov/pubmed/35773327 http://dx.doi.org/10.1038/s42003-022-03600-9 |
work_keys_str_mv | AT jarabopatricia alignmentbetweenglioblastomainternalclockandenvironmentalcuesamelioratessurvivalindrosophila AT barredoceliag alignmentbetweenglioblastomainternalclockandenvironmentalcuesamelioratessurvivalindrosophila AT depablocarmen alignmentbetweenglioblastomainternalclockandenvironmentalcuesamelioratessurvivalindrosophila AT casastintosergio alignmentbetweenglioblastomainternalclockandenvironmentalcuesamelioratessurvivalindrosophila AT martinfranciscoa alignmentbetweenglioblastomainternalclockandenvironmentalcuesamelioratessurvivalindrosophila |