Cargando…

Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila

Virtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively st...

Descripción completa

Detalles Bibliográficos
Autores principales: Jarabo, Patricia, Barredo, Celia G., de Pablo, Carmen, Casas-Tinto, Sergio, Martin, Francisco A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247055/
https://www.ncbi.nlm.nih.gov/pubmed/35773327
http://dx.doi.org/10.1038/s42003-022-03600-9
_version_ 1784739066437173248
author Jarabo, Patricia
Barredo, Celia G.
de Pablo, Carmen
Casas-Tinto, Sergio
Martin, Francisco A.
author_facet Jarabo, Patricia
Barredo, Celia G.
de Pablo, Carmen
Casas-Tinto, Sergio
Martin, Francisco A.
author_sort Jarabo, Patricia
collection PubMed
description Virtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively studied on cancer. Still, mechanisms underlying these alterations, and how they favor tumor development remain largely unknown. Here, we show that glioblastoma-induced neurodegeneration also causes circadian alterations in Drosophila. Preventing neurodegeneration in all neurons by genetic means reestablishes normal biological rhythms. Interestingly, in early stages of tumor development, the central pacemaker lengthens its period, whereas in later stages this is severely disrupted. The re-adjustment of the external light:dark period to longer glioblastoma-induced internal rhythms delays glioblastoma progression and ameliorates associated deleterious effects, even after the tumor onset.
format Online
Article
Text
id pubmed-9247055
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-92470552022-07-02 Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila Jarabo, Patricia Barredo, Celia G. de Pablo, Carmen Casas-Tinto, Sergio Martin, Francisco A. Commun Biol Article Virtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively studied on cancer. Still, mechanisms underlying these alterations, and how they favor tumor development remain largely unknown. Here, we show that glioblastoma-induced neurodegeneration also causes circadian alterations in Drosophila. Preventing neurodegeneration in all neurons by genetic means reestablishes normal biological rhythms. Interestingly, in early stages of tumor development, the central pacemaker lengthens its period, whereas in later stages this is severely disrupted. The re-adjustment of the external light:dark period to longer glioblastoma-induced internal rhythms delays glioblastoma progression and ameliorates associated deleterious effects, even after the tumor onset. Nature Publishing Group UK 2022-06-30 /pmc/articles/PMC9247055/ /pubmed/35773327 http://dx.doi.org/10.1038/s42003-022-03600-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Jarabo, Patricia
Barredo, Celia G.
de Pablo, Carmen
Casas-Tinto, Sergio
Martin, Francisco A.
Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title_full Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title_fullStr Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title_full_unstemmed Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title_short Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title_sort alignment between glioblastoma internal clock and environmental cues ameliorates survival in drosophila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247055/
https://www.ncbi.nlm.nih.gov/pubmed/35773327
http://dx.doi.org/10.1038/s42003-022-03600-9
work_keys_str_mv AT jarabopatricia alignmentbetweenglioblastomainternalclockandenvironmentalcuesamelioratessurvivalindrosophila
AT barredoceliag alignmentbetweenglioblastomainternalclockandenvironmentalcuesamelioratessurvivalindrosophila
AT depablocarmen alignmentbetweenglioblastomainternalclockandenvironmentalcuesamelioratessurvivalindrosophila
AT casastintosergio alignmentbetweenglioblastomainternalclockandenvironmentalcuesamelioratessurvivalindrosophila
AT martinfranciscoa alignmentbetweenglioblastomainternalclockandenvironmentalcuesamelioratessurvivalindrosophila