p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1

Aggregation of misfolded alpha-synuclein (α-synuclein) is a central player in the pathogenesis of neurodegenerative diseases. Therefore, the regulatory mechanism underlying α-synuclein aggregation has been intensively studied in Parkinson’s disease (PD) but remains poorly understood. Here, we report...

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Detalles Bibliográficos
Autores principales: Won, So-Yoon, Park, Jung-Jin, You, Soon-Tae, Hyeun, Jong-A, Kim, Hyong-Kyu, Jin, Byung Kwan, McLean, Catriona, Shin, Eun-Young, Kim, Eung-Gook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247077/
https://www.ncbi.nlm.nih.gov/pubmed/35773260
http://dx.doi.org/10.1038/s41419-022-05030-1

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