Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing

Universal CAR T-cell therapies are poised to revolutionize cancer treatment and to improve patient outcomes. However, realizing these advantages in an allogeneic setting requires universal CAR T-cells that can kill target tumor cells, avoid depletion by the host immune system, and proliferate withou...

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Detalles Bibliográficos
Autores principales: Jo, Sumin, Das, Shipra, Williams, Alan, Chretien, Anne-Sophie, Pagliardini, Thomas, Le Roy, Aude, Fernandez, Jorge Postigo, Le Clerre, Diane, Jahangiri, Billal, Chion-Sotinel, Isabelle, Rozlan, Sandra, Dessez, Emilie, Gouble, Agnes, Dusséaux, Mathilde, Galetto, Roman, Duclert, Aymeric, Marcenaro, Emanuela, Devillier, Raynier, Olive, Daniel, Duchateau, Philippe, Poirot, Laurent, Valton, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247096/
https://www.ncbi.nlm.nih.gov/pubmed/35773273
http://dx.doi.org/10.1038/s41467-022-30896-2

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