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CD137 Costimulation Enhances the Antitumor Activity of Vγ9Vδ2-T Cells in IL-10-Mediated Immunosuppressive Tumor Microenvironment

Although γδ-T cell-based tumor immunotherapy using phosphoantigens to boost γδ-T cell immunity has shown success in some cancer patients, the clinical application is limited due to the rapid exhaustion of Vγ9Vδ2-T cells caused by repetitive stimulation from phosphoantigens and the profoundly immunos...

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Detalles Bibliográficos
Autores principales:	Pei, Yujun, Xiang, Zheng, Wen, Kun, Tu, Chloe Ran, Wang, Xiwei, Zhang, Yanmei, Mu, Xiaofeng, Liu, Yinping, Tu, Wenwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247142/ https://www.ncbi.nlm.nih.gov/pubmed/35784354 http://dx.doi.org/10.3389/fimmu.2022.872122

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