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Mapping of the sGC Stimulator BAY 41-2272 Binding Site on H-NOX Domain and Its Regulation by the Redox State of the Heme

Soluble guanylate cyclase (sGC) is the main receptor of nitric oxide (NO) and by converting GTP to cGMP regulates numerous biological processes. The β1 subunit of the most abundant, α1β1 heterodimer, harbors an N-terminal domain called H-NOX, responsible for heme and NO binding and thus sGC activati...

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Detalles Bibliográficos
Autores principales:	Makrynitsa, Garyfallia I., Argyriou, Aikaterini I., Zompra, Aikaterini A., Salagiannis, Konstantinos, Vazoura, Vassiliki, Papapetropoulos, Andreas, Topouzis, Stavros, Spyroulias, Georgios A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247194/ https://www.ncbi.nlm.nih.gov/pubmed/35784456 http://dx.doi.org/10.3389/fcell.2022.925457

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