Heterologous booster COVID-19 vaccination elicited potent immune responses in HCWs

The objective of our study was to evaluate the antibody responses of health care workers (HCWs) who were vaccinated with booster dose BNT162b2 6 months after 2 doses of the CoronoVac vaccine. The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD...

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Detalles Bibliográficos
Autores principales: Saltoğlu, Neşe, Dinç, Harika Öykü, Balkan, İlker İnanç, Can, Günay, Özbey, Doğukan, Beytur, Ayşe Nur, Keskin, Elif, Budak, Beyhan, Aydoğan, Okan, Mete, Bilgül, Karaali, Rıdvan, Ergin, Sevgi, Kocazeybek, Bekir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Virology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247219/
https://www.ncbi.nlm.nih.gov/pubmed/35878507
http://dx.doi.org/10.1016/j.diagmicrobio.2022.115758
Descripción
Sumario:The objective of our study was to evaluate the antibody responses of health care workers (HCWs) who were vaccinated with booster dose BNT162b2 6 months after 2 doses of the CoronoVac vaccine. The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD IgG levels were measured immediately before and 1 month after the booster dose. In the sixth month after CoronaVac vaccination, the median of antibody levels of 1212.02 AU/ML, while it was 9283 AU/mL after BNT162b2 vaccination. IgG antibody titers of over 1050 AU/mL (which is equivalent to 1:80 dilution in the plaque reduction neutralization test) were detected in HCWs 15.09% and 97.8%, respectively. Our results showed that antibody titers increased 8-fold after the booster dose. We believe that the administration of the mRNA vaccine as a booster dose can provide more effective protection against COVID-19 infection, especially in individuals with risk factors.

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