The Great Majority of Homologous Recombination Repair-Deficient Tumors Are Accounted for by Established Causes

Background: Gene-agnostic genomic biomarkers were recently developed to identify homologous recombination deficiency (HRD) tumors that are likely to respond to treatment with PARP inhibitors. Two machine-learning algorithms that predict HRD status, CHORD, and HRDetect, utilize various HRD-associated...

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Detalles Bibliográficos
Autores principales: Štancl, Paula, Hamel, Nancy, Sigel, Keith M., Foulkes, William D., Karlić, Rosa, Polak, Paz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247292/
https://www.ncbi.nlm.nih.gov/pubmed/35783256
http://dx.doi.org/10.3389/fgene.2022.852159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247292/
https://www.ncbi.nlm.nih.gov/pubmed/35783256
http://dx.doi.org/10.3389/fgene.2022.852159

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