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The Great Majority of Homologous Recombination Repair-Deficient Tumors Are Accounted for by Established Causes

Background: Gene-agnostic genomic biomarkers were recently developed to identify homologous recombination deficiency (HRD) tumors that are likely to respond to treatment with PARP inhibitors. Two machine-learning algorithms that predict HRD status, CHORD, and HRDetect, utilize various HRD-associated...

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Detalles Bibliográficos
Autores principales:	Štancl, Paula, Hamel, Nancy, Sigel, Keith M., Foulkes, William D., Karlić, Rosa, Polak, Paz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247292/ https://www.ncbi.nlm.nih.gov/pubmed/35783256 http://dx.doi.org/10.3389/fgene.2022.852159

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