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Genetic Characterization and Population Connectedness of North American and European Dairy Goats

Genomic prediction of breeding values is routinely performed in several livestock breeding programs around the world, but the size of the training populations and the genetic structure of populations evaluated have, in many instances, limited the increase in the accuracy of genomic estimated breedin...

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Autores principales: Teissier, Marc, Brito, Luiz F., Schenkel, Flavio S., Bruni, Guido, Fresi, Pancrazio, Bapst, Beat, Robert-Granie, Christèle, Larroque, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247305/
https://www.ncbi.nlm.nih.gov/pubmed/35783257
http://dx.doi.org/10.3389/fgene.2022.862838
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author Teissier, Marc
Brito, Luiz F.
Schenkel, Flavio S.
Bruni, Guido
Fresi, Pancrazio
Bapst, Beat
Robert-Granie, Christèle
Larroque, Hélène
author_facet Teissier, Marc
Brito, Luiz F.
Schenkel, Flavio S.
Bruni, Guido
Fresi, Pancrazio
Bapst, Beat
Robert-Granie, Christèle
Larroque, Hélène
author_sort Teissier, Marc
collection PubMed
description Genomic prediction of breeding values is routinely performed in several livestock breeding programs around the world, but the size of the training populations and the genetic structure of populations evaluated have, in many instances, limited the increase in the accuracy of genomic estimated breeding values. Combining phenotypic, pedigree, and genomic data from genetically related populations can be a feasible strategy to overcome this limitation. However, the success of across-population genetic evaluations depends on the pedigree connectedness and genetic relationship among individuals from different populations. In this context, this study aimed to evaluate the genetic connectedness and population structure of Alpine and Saanen dairy goats from four countries involved in the European project SMARTER (SMAll RuminanTs Breeding for Efficiency and Resilience), including Canada, France, Italy, and Switzerland. These analyses are paramount for assessing the potential feasibility of an across-country genomic evaluation in dairy goats. Approximately, 9,855 genotyped individuals (with 51% French genotyped animals) and 6,435,189 animals included in the pedigree files were available across all four populations. The pedigree analyses indicated that the exchange of breeding animals was mainly unilateral with flows from France to the other three countries. Italy has also imported breeding animals from Switzerland. Principal component analyses (PCAs), genetic admixture analysis, and consistency of the gametic phase revealed that French and Italian populations are more genetically related than the other dairy goat population pairs. Canadian dairy goats showed the largest within-breed heterogeneity and genetic differences with the European populations. The genetic diversity and population connectedness between the studied populations indicated that an international genomic evaluation may be more feasible, especially for French and Italian goats. Further studies will investigate the accuracy of genomic breeding values when combining the datasets from these four populations.
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spelling pubmed-92473052022-07-02 Genetic Characterization and Population Connectedness of North American and European Dairy Goats Teissier, Marc Brito, Luiz F. Schenkel, Flavio S. Bruni, Guido Fresi, Pancrazio Bapst, Beat Robert-Granie, Christèle Larroque, Hélène Front Genet Genetics Genomic prediction of breeding values is routinely performed in several livestock breeding programs around the world, but the size of the training populations and the genetic structure of populations evaluated have, in many instances, limited the increase in the accuracy of genomic estimated breeding values. Combining phenotypic, pedigree, and genomic data from genetically related populations can be a feasible strategy to overcome this limitation. However, the success of across-population genetic evaluations depends on the pedigree connectedness and genetic relationship among individuals from different populations. In this context, this study aimed to evaluate the genetic connectedness and population structure of Alpine and Saanen dairy goats from four countries involved in the European project SMARTER (SMAll RuminanTs Breeding for Efficiency and Resilience), including Canada, France, Italy, and Switzerland. These analyses are paramount for assessing the potential feasibility of an across-country genomic evaluation in dairy goats. Approximately, 9,855 genotyped individuals (with 51% French genotyped animals) and 6,435,189 animals included in the pedigree files were available across all four populations. The pedigree analyses indicated that the exchange of breeding animals was mainly unilateral with flows from France to the other three countries. Italy has also imported breeding animals from Switzerland. Principal component analyses (PCAs), genetic admixture analysis, and consistency of the gametic phase revealed that French and Italian populations are more genetically related than the other dairy goat population pairs. Canadian dairy goats showed the largest within-breed heterogeneity and genetic differences with the European populations. The genetic diversity and population connectedness between the studied populations indicated that an international genomic evaluation may be more feasible, especially for French and Italian goats. Further studies will investigate the accuracy of genomic breeding values when combining the datasets from these four populations. Frontiers Media S.A. 2022-06-17 /pmc/articles/PMC9247305/ /pubmed/35783257 http://dx.doi.org/10.3389/fgene.2022.862838 Text en Copyright © 2022 Teissier, Brito, Schenkel, Bruni, Fresi, Bapst, Robert-Granie and Larroque. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Teissier, Marc
Brito, Luiz F.
Schenkel, Flavio S.
Bruni, Guido
Fresi, Pancrazio
Bapst, Beat
Robert-Granie, Christèle
Larroque, Hélène
Genetic Characterization and Population Connectedness of North American and European Dairy Goats
title Genetic Characterization and Population Connectedness of North American and European Dairy Goats
title_full Genetic Characterization and Population Connectedness of North American and European Dairy Goats
title_fullStr Genetic Characterization and Population Connectedness of North American and European Dairy Goats
title_full_unstemmed Genetic Characterization and Population Connectedness of North American and European Dairy Goats
title_short Genetic Characterization and Population Connectedness of North American and European Dairy Goats
title_sort genetic characterization and population connectedness of north american and european dairy goats
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247305/
https://www.ncbi.nlm.nih.gov/pubmed/35783257
http://dx.doi.org/10.3389/fgene.2022.862838
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