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Food for Thought: Leptin and Hippocampal Synaptic Function
It is well documented that the endocrine hormone, leptin controls energy homeostasis by providing key signals to specific hypothalamic nuclei. However, our knowledge of leptin’s central actions has advanced considerably over the last 20 years, with the hippocampus now established as an important bra...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247348/ https://www.ncbi.nlm.nih.gov/pubmed/35784728 http://dx.doi.org/10.3389/fphar.2022.882158 |
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author | Harvey, Jenni |
author_facet | Harvey, Jenni |
author_sort | Harvey, Jenni |
collection | PubMed |
description | It is well documented that the endocrine hormone, leptin controls energy homeostasis by providing key signals to specific hypothalamic nuclei. However, our knowledge of leptin’s central actions has advanced considerably over the last 20 years, with the hippocampus now established as an important brain target for this hormone. Leptin receptors are highly localised to hippocampal synapses, and increasing evidence reveals that activation of synaptically located leptin receptors markedly impacts cognitive processes, and specifically hippocampal-dependent learning and memory. Here, we review the recent actions of leptin at hippocampal synapses and explore the consequences for brain health and disease. |
format | Online Article Text |
id | pubmed-9247348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92473482022-07-02 Food for Thought: Leptin and Hippocampal Synaptic Function Harvey, Jenni Front Pharmacol Pharmacology It is well documented that the endocrine hormone, leptin controls energy homeostasis by providing key signals to specific hypothalamic nuclei. However, our knowledge of leptin’s central actions has advanced considerably over the last 20 years, with the hippocampus now established as an important brain target for this hormone. Leptin receptors are highly localised to hippocampal synapses, and increasing evidence reveals that activation of synaptically located leptin receptors markedly impacts cognitive processes, and specifically hippocampal-dependent learning and memory. Here, we review the recent actions of leptin at hippocampal synapses and explore the consequences for brain health and disease. Frontiers Media S.A. 2022-06-17 /pmc/articles/PMC9247348/ /pubmed/35784728 http://dx.doi.org/10.3389/fphar.2022.882158 Text en Copyright © 2022 Harvey. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Harvey, Jenni Food for Thought: Leptin and Hippocampal Synaptic Function |
title | Food for Thought: Leptin and Hippocampal Synaptic Function |
title_full | Food for Thought: Leptin and Hippocampal Synaptic Function |
title_fullStr | Food for Thought: Leptin and Hippocampal Synaptic Function |
title_full_unstemmed | Food for Thought: Leptin and Hippocampal Synaptic Function |
title_short | Food for Thought: Leptin and Hippocampal Synaptic Function |
title_sort | food for thought: leptin and hippocampal synaptic function |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247348/ https://www.ncbi.nlm.nih.gov/pubmed/35784728 http://dx.doi.org/10.3389/fphar.2022.882158 |
work_keys_str_mv | AT harveyjenni foodforthoughtleptinandhippocampalsynapticfunction |