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Food for Thought: Leptin and Hippocampal Synaptic Function

It is well documented that the endocrine hormone, leptin controls energy homeostasis by providing key signals to specific hypothalamic nuclei. However, our knowledge of leptin’s central actions has advanced considerably over the last 20 years, with the hippocampus now established as an important bra...

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Detalles Bibliográficos
Autor principal: Harvey, Jenni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247348/
https://www.ncbi.nlm.nih.gov/pubmed/35784728
http://dx.doi.org/10.3389/fphar.2022.882158
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author Harvey, Jenni
author_facet Harvey, Jenni
author_sort Harvey, Jenni
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description It is well documented that the endocrine hormone, leptin controls energy homeostasis by providing key signals to specific hypothalamic nuclei. However, our knowledge of leptin’s central actions has advanced considerably over the last 20 years, with the hippocampus now established as an important brain target for this hormone. Leptin receptors are highly localised to hippocampal synapses, and increasing evidence reveals that activation of synaptically located leptin receptors markedly impacts cognitive processes, and specifically hippocampal-dependent learning and memory. Here, we review the recent actions of leptin at hippocampal synapses and explore the consequences for brain health and disease.
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spelling pubmed-92473482022-07-02 Food for Thought: Leptin and Hippocampal Synaptic Function Harvey, Jenni Front Pharmacol Pharmacology It is well documented that the endocrine hormone, leptin controls energy homeostasis by providing key signals to specific hypothalamic nuclei. However, our knowledge of leptin’s central actions has advanced considerably over the last 20 years, with the hippocampus now established as an important brain target for this hormone. Leptin receptors are highly localised to hippocampal synapses, and increasing evidence reveals that activation of synaptically located leptin receptors markedly impacts cognitive processes, and specifically hippocampal-dependent learning and memory. Here, we review the recent actions of leptin at hippocampal synapses and explore the consequences for brain health and disease. Frontiers Media S.A. 2022-06-17 /pmc/articles/PMC9247348/ /pubmed/35784728 http://dx.doi.org/10.3389/fphar.2022.882158 Text en Copyright © 2022 Harvey. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Harvey, Jenni
Food for Thought: Leptin and Hippocampal Synaptic Function
title Food for Thought: Leptin and Hippocampal Synaptic Function
title_full Food for Thought: Leptin and Hippocampal Synaptic Function
title_fullStr Food for Thought: Leptin and Hippocampal Synaptic Function
title_full_unstemmed Food for Thought: Leptin and Hippocampal Synaptic Function
title_short Food for Thought: Leptin and Hippocampal Synaptic Function
title_sort food for thought: leptin and hippocampal synaptic function
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247348/
https://www.ncbi.nlm.nih.gov/pubmed/35784728
http://dx.doi.org/10.3389/fphar.2022.882158
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