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Genome Analysis of Goose-Origin Astroviruses Causing Fatal Gout in Shanghai, China Reveals One of Them Belonging to a Novel Type Is a Recombinant Strain

Since 2014, a goose-origin astroviruses disease, which is characterized by urate precipitation in viscera, has rapidly spread to major commercial goose provinces leading to huge economic losses in the poultry industry of China. In March 2020, a goose farm locates in Shanghai, China, where there was...

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Autores principales: Shen, Quan, Zhuang, Zi, Lu, Juan, Qian, Lingling, Li, Guangquan, Kanton, Aaron Gia, Yang, Shixing, Wang, Xiaochun, Wang, Huiying, Yin, Jun, Zhang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247502/
https://www.ncbi.nlm.nih.gov/pubmed/35782540
http://dx.doi.org/10.3389/fvets.2022.878441
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author Shen, Quan
Zhuang, Zi
Lu, Juan
Qian, Lingling
Li, Guangquan
Kanton, Aaron Gia
Yang, Shixing
Wang, Xiaochun
Wang, Huiying
Yin, Jun
Zhang, Wen
author_facet Shen, Quan
Zhuang, Zi
Lu, Juan
Qian, Lingling
Li, Guangquan
Kanton, Aaron Gia
Yang, Shixing
Wang, Xiaochun
Wang, Huiying
Yin, Jun
Zhang, Wen
author_sort Shen, Quan
collection PubMed
description Since 2014, a goose-origin astroviruses disease, which is characterized by urate precipitation in viscera, has rapidly spread to major commercial goose provinces leading to huge economic losses in the poultry industry of China. In March 2020, a goose farm locates in Shanghai, China, where there was no goose astroviruses (GAstVs) infection reported before, experienced an outbreak of gout disease in geese. The etiological investigation was carried out by virus metagenomics and bacterial culture and two GAstVs strains, designated as CHSH01 and CHSH02, were determined. Their complete genomes were measured to 7,154 and 7,330 nt in length, excludingthe poly(A) tail, respectively, and had different genomic features and classifications. CHSH01 shared a very low sequence identity with other strains in terms of not only the complete genome but also different ORFs. Phylogenetic analysis showed CHSH02 belonged to GAstV-2, which was the predominant species in the geese with gout in China according to the previous study. Meanwhile, CHSH01 strain displayed low identity with other AstVs, and phylogenetic and recombination analysis suggested that CHSH01 belonging to a novel type was a recombinant strain, one parent strain of which was an AstV determined from a bar-headed goose (a kind of migrant bird). Moreover, the primary epidemiological investigation showed that the two strains were prevalent in the same goose farm and co-infection occurred. These findings arise the potential cross-species transmission of CHSH01 between domestic and wild fowl.
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spelling pubmed-92475022022-07-02 Genome Analysis of Goose-Origin Astroviruses Causing Fatal Gout in Shanghai, China Reveals One of Them Belonging to a Novel Type Is a Recombinant Strain Shen, Quan Zhuang, Zi Lu, Juan Qian, Lingling Li, Guangquan Kanton, Aaron Gia Yang, Shixing Wang, Xiaochun Wang, Huiying Yin, Jun Zhang, Wen Front Vet Sci Veterinary Science Since 2014, a goose-origin astroviruses disease, which is characterized by urate precipitation in viscera, has rapidly spread to major commercial goose provinces leading to huge economic losses in the poultry industry of China. In March 2020, a goose farm locates in Shanghai, China, where there was no goose astroviruses (GAstVs) infection reported before, experienced an outbreak of gout disease in geese. The etiological investigation was carried out by virus metagenomics and bacterial culture and two GAstVs strains, designated as CHSH01 and CHSH02, were determined. Their complete genomes were measured to 7,154 and 7,330 nt in length, excludingthe poly(A) tail, respectively, and had different genomic features and classifications. CHSH01 shared a very low sequence identity with other strains in terms of not only the complete genome but also different ORFs. Phylogenetic analysis showed CHSH02 belonged to GAstV-2, which was the predominant species in the geese with gout in China according to the previous study. Meanwhile, CHSH01 strain displayed low identity with other AstVs, and phylogenetic and recombination analysis suggested that CHSH01 belonging to a novel type was a recombinant strain, one parent strain of which was an AstV determined from a bar-headed goose (a kind of migrant bird). Moreover, the primary epidemiological investigation showed that the two strains were prevalent in the same goose farm and co-infection occurred. These findings arise the potential cross-species transmission of CHSH01 between domestic and wild fowl. Frontiers Media S.A. 2022-06-17 /pmc/articles/PMC9247502/ /pubmed/35782540 http://dx.doi.org/10.3389/fvets.2022.878441 Text en Copyright © 2022 Shen, Zhuang, Lu, Qian, Li, Kanton, Yang, Wang, Wang, Yin and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Shen, Quan
Zhuang, Zi
Lu, Juan
Qian, Lingling
Li, Guangquan
Kanton, Aaron Gia
Yang, Shixing
Wang, Xiaochun
Wang, Huiying
Yin, Jun
Zhang, Wen
Genome Analysis of Goose-Origin Astroviruses Causing Fatal Gout in Shanghai, China Reveals One of Them Belonging to a Novel Type Is a Recombinant Strain
title Genome Analysis of Goose-Origin Astroviruses Causing Fatal Gout in Shanghai, China Reveals One of Them Belonging to a Novel Type Is a Recombinant Strain
title_full Genome Analysis of Goose-Origin Astroviruses Causing Fatal Gout in Shanghai, China Reveals One of Them Belonging to a Novel Type Is a Recombinant Strain
title_fullStr Genome Analysis of Goose-Origin Astroviruses Causing Fatal Gout in Shanghai, China Reveals One of Them Belonging to a Novel Type Is a Recombinant Strain
title_full_unstemmed Genome Analysis of Goose-Origin Astroviruses Causing Fatal Gout in Shanghai, China Reveals One of Them Belonging to a Novel Type Is a Recombinant Strain
title_short Genome Analysis of Goose-Origin Astroviruses Causing Fatal Gout in Shanghai, China Reveals One of Them Belonging to a Novel Type Is a Recombinant Strain
title_sort genome analysis of goose-origin astroviruses causing fatal gout in shanghai, china reveals one of them belonging to a novel type is a recombinant strain
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247502/
https://www.ncbi.nlm.nih.gov/pubmed/35782540
http://dx.doi.org/10.3389/fvets.2022.878441
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