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Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering

INTRODUCTION: Antibiotics have been used as an adjunct in treating children with severe acute malnutrition 6–59 months of age; however, the data for infants less than 6 months are scarce. The WHO recently started guideline development for preventing and treating wasting, including growth failure/fal...

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Autores principales: Imdad, Aamer, Chen, Fanny F, François, Melissa, Tanner-Smith, Emily, Smith, Abigail, Tsistinas, Olivia J, Das, Jai K, Bhutta, Zulfiqar Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247651/
https://www.ncbi.nlm.nih.gov/pubmed/35772832
http://dx.doi.org/10.1136/bmjopen-2021-057241
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author Imdad, Aamer
Chen, Fanny F
François, Melissa
Tanner-Smith, Emily
Smith, Abigail
Tsistinas, Olivia J
Das, Jai K
Bhutta, Zulfiqar Ahmed
author_facet Imdad, Aamer
Chen, Fanny F
François, Melissa
Tanner-Smith, Emily
Smith, Abigail
Tsistinas, Olivia J
Das, Jai K
Bhutta, Zulfiqar Ahmed
author_sort Imdad, Aamer
collection PubMed
description INTRODUCTION: Antibiotics have been used as an adjunct in treating children with severe acute malnutrition 6–59 months of age; however, the data for infants less than 6 months are scarce. The WHO recently started guideline development for preventing and treating wasting, including growth failure/faltering in infants less than 6 months. This systematic review commissioned by WHO aims to synthesise evidence from current literature on the effectiveness of antibiotics for infants less than 6 months of age with growth failure/faltering. METHODS AND ANALYSIS: We will conduct a systematic review and meta-analysis for studies that assessed the effect of antibiotics in the treatment of infants with growth faltering. We will search multiple electronic databases. We will include randomised control trials and non-randomised studies with a control arm. The study population is infants less than 6 months of age with growth failure. The intervention group will be infants who received no antibiotics or antibiotics other than recommended in 2013 guidelines by WHO to treat severe acute malnutrition in children. The comparison group will be infants who received antibiotics according to the 2013 guideline by WHO. We will consider the following outcomes: mortality, clinical deterioration, antimicrobial resistance, recovery from comorbidity, adverse events, markers of intestinal inflammation, markers of systemic inflammation, hospital-acquired infections, non-response. We will use the meta-analysis to pool the studies where applicable. We will use the Grading of Recommendations Assessment, Development, and Evaluation approach to reporting the overall evidence quality for an outcome. ETHICS AND DISSEMINATION: This is a systematic review and will not involve contact with a human subject. The findings of this review will be published in a peer-review journal and will guide the WHO’s recommendation for the use of antibiotics in infants less than 6 months of age with growth failure. PROSPERO REGISTRATION NUMBER: CRD42021277073.
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spelling pubmed-92476512022-07-14 Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering Imdad, Aamer Chen, Fanny F François, Melissa Tanner-Smith, Emily Smith, Abigail Tsistinas, Olivia J Das, Jai K Bhutta, Zulfiqar Ahmed BMJ Open Paediatrics INTRODUCTION: Antibiotics have been used as an adjunct in treating children with severe acute malnutrition 6–59 months of age; however, the data for infants less than 6 months are scarce. The WHO recently started guideline development for preventing and treating wasting, including growth failure/faltering in infants less than 6 months. This systematic review commissioned by WHO aims to synthesise evidence from current literature on the effectiveness of antibiotics for infants less than 6 months of age with growth failure/faltering. METHODS AND ANALYSIS: We will conduct a systematic review and meta-analysis for studies that assessed the effect of antibiotics in the treatment of infants with growth faltering. We will search multiple electronic databases. We will include randomised control trials and non-randomised studies with a control arm. The study population is infants less than 6 months of age with growth failure. The intervention group will be infants who received no antibiotics or antibiotics other than recommended in 2013 guidelines by WHO to treat severe acute malnutrition in children. The comparison group will be infants who received antibiotics according to the 2013 guideline by WHO. We will consider the following outcomes: mortality, clinical deterioration, antimicrobial resistance, recovery from comorbidity, adverse events, markers of intestinal inflammation, markers of systemic inflammation, hospital-acquired infections, non-response. We will use the meta-analysis to pool the studies where applicable. We will use the Grading of Recommendations Assessment, Development, and Evaluation approach to reporting the overall evidence quality for an outcome. ETHICS AND DISSEMINATION: This is a systematic review and will not involve contact with a human subject. The findings of this review will be published in a peer-review journal and will guide the WHO’s recommendation for the use of antibiotics in infants less than 6 months of age with growth failure. PROSPERO REGISTRATION NUMBER: CRD42021277073. BMJ Publishing Group 2022-06-30 /pmc/articles/PMC9247651/ /pubmed/35772832 http://dx.doi.org/10.1136/bmjopen-2021-057241 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Paediatrics
Imdad, Aamer
Chen, Fanny F
François, Melissa
Tanner-Smith, Emily
Smith, Abigail
Tsistinas, Olivia J
Das, Jai K
Bhutta, Zulfiqar Ahmed
Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering
title Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering
title_full Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering
title_fullStr Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering
title_full_unstemmed Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering
title_short Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering
title_sort protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering
topic Paediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247651/
https://www.ncbi.nlm.nih.gov/pubmed/35772832
http://dx.doi.org/10.1136/bmjopen-2021-057241
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