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Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs

Rap1 GTPase drives assembly of the Mig-10/RIAM/Lamellipodin (MRL protein)–integrin–talin (MIT) complex that enables integrin-dependent lymphocyte functions. Here we used tandem affinity tag–based proteomics to isolate and analyze the MIT complex and reveal that Phostensin (Ptsn), a regulatory subuni...

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Detalles Bibliográficos
Autores principales:	Lee, Ho-Sup, Sun, Hao, Lagarrigue, Frédéric, Kim, Sarah Hyun Ji, Fox, Jay W., Sherman, Nicholas E., Gingras, Alexandre R., Ginsberg, Mark H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247717/ https://www.ncbi.nlm.nih.gov/pubmed/35766979 http://dx.doi.org/10.1084/jem.20211637

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