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Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis

Multiple sclerosis (MS) is a highly debilitating autoimmune disease affecting millions of individuals worldwide. Although classically viewed as T-cell mediated disease, the role of innate lymphoid cells (ILC) such as natural killer (NK) cells and ILC 1-3s has become a focal point as several findings...

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Autores principales: Sadeghi Hassanabadi, Negar, Broux, Bieke, Marinović, Sonja, Gotthardt, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247827/
https://www.ncbi.nlm.nih.gov/pubmed/35784374
http://dx.doi.org/10.3389/fimmu.2022.909275
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author Sadeghi Hassanabadi, Negar
Broux, Bieke
Marinović, Sonja
Gotthardt, Dagmar
author_facet Sadeghi Hassanabadi, Negar
Broux, Bieke
Marinović, Sonja
Gotthardt, Dagmar
author_sort Sadeghi Hassanabadi, Negar
collection PubMed
description Multiple sclerosis (MS) is a highly debilitating autoimmune disease affecting millions of individuals worldwide. Although classically viewed as T-cell mediated disease, the role of innate lymphoid cells (ILC) such as natural killer (NK) cells and ILC 1-3s has become a focal point as several findings implicate them in the disease pathology. The role of ILCs in MS is still not completely understood as controversial findings have been reported assigning them either a protective or disease-accelerating role. Recent findings in experimental autoimmune encephalomyelitis (EAE) suggest that ILCs infiltrate the central nervous system (CNS), mediate inflammation, and have a disease exacerbating role by influencing the recruitment of autoreactive T-cells. Elucidating the detailed role of ILCs and altered signaling pathways in MS is essential for a more complete picture of the disease pathology and novel therapeutic targets. We here review the current knowledge about ILCs in the development and progression of MS and preclinical models of MS and discuss their potential for therapeutic applications.
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spelling pubmed-92478272022-07-02 Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis Sadeghi Hassanabadi, Negar Broux, Bieke Marinović, Sonja Gotthardt, Dagmar Front Immunol Immunology Multiple sclerosis (MS) is a highly debilitating autoimmune disease affecting millions of individuals worldwide. Although classically viewed as T-cell mediated disease, the role of innate lymphoid cells (ILC) such as natural killer (NK) cells and ILC 1-3s has become a focal point as several findings implicate them in the disease pathology. The role of ILCs in MS is still not completely understood as controversial findings have been reported assigning them either a protective or disease-accelerating role. Recent findings in experimental autoimmune encephalomyelitis (EAE) suggest that ILCs infiltrate the central nervous system (CNS), mediate inflammation, and have a disease exacerbating role by influencing the recruitment of autoreactive T-cells. Elucidating the detailed role of ILCs and altered signaling pathways in MS is essential for a more complete picture of the disease pathology and novel therapeutic targets. We here review the current knowledge about ILCs in the development and progression of MS and preclinical models of MS and discuss their potential for therapeutic applications. Frontiers Media S.A. 2022-06-17 /pmc/articles/PMC9247827/ /pubmed/35784374 http://dx.doi.org/10.3389/fimmu.2022.909275 Text en Copyright © 2022 Sadeghi Hassanabadi, Broux, Marinović and Gotthardt https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sadeghi Hassanabadi, Negar
Broux, Bieke
Marinović, Sonja
Gotthardt, Dagmar
Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis
title Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis
title_full Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis
title_fullStr Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis
title_full_unstemmed Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis
title_short Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis
title_sort innate lymphoid cells - neglected players in multiple sclerosis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247827/
https://www.ncbi.nlm.nih.gov/pubmed/35784374
http://dx.doi.org/10.3389/fimmu.2022.909275
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