Cargando…
Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review
ABSTRACT: Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in children. The ability of healthcare providers to diagnose and prognose LRTIs in the pediatric population remains a challenge, as children can present with similar clinical features regardless of th...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247944/ https://www.ncbi.nlm.nih.gov/pubmed/35778499 http://dx.doi.org/10.1038/s41390-022-02162-0 |
_version_ | 1784739268380327936 |
---|---|
author | Wildman, Emily Mickiewicz, Beata Vogel, Hans J. Thompson, Graham C. |
author_facet | Wildman, Emily Mickiewicz, Beata Vogel, Hans J. Thompson, Graham C. |
author_sort | Wildman, Emily |
collection | PubMed |
description | ABSTRACT: Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in children. The ability of healthcare providers to diagnose and prognose LRTIs in the pediatric population remains a challenge, as children can present with similar clinical features regardless of the underlying pathogen or ultimate severity. Metabolomics, the large-scale analysis of metabolites and metabolic pathways offers new tools and insights that may aid in diagnosing and predicting the outcomes of LRTIs in children. This review highlights the latest literature on the clinical utility of metabolomics in providing care for children with bronchiolitis, pneumonia, COVID-19, and sepsis. IMPACT: This article summarizes current metabolomics approaches to diagnosing and predicting the course of pediatric lower respiratory infections. This article highlights the limitations to current metabolomics research and highlights future directions for the field. |
format | Online Article Text |
id | pubmed-9247944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-92479442022-07-01 Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review Wildman, Emily Mickiewicz, Beata Vogel, Hans J. Thompson, Graham C. Pediatr Res Review Article ABSTRACT: Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in children. The ability of healthcare providers to diagnose and prognose LRTIs in the pediatric population remains a challenge, as children can present with similar clinical features regardless of the underlying pathogen or ultimate severity. Metabolomics, the large-scale analysis of metabolites and metabolic pathways offers new tools and insights that may aid in diagnosing and predicting the outcomes of LRTIs in children. This review highlights the latest literature on the clinical utility of metabolomics in providing care for children with bronchiolitis, pneumonia, COVID-19, and sepsis. IMPACT: This article summarizes current metabolomics approaches to diagnosing and predicting the course of pediatric lower respiratory infections. This article highlights the limitations to current metabolomics research and highlights future directions for the field. Nature Publishing Group US 2022-07-01 2023 /pmc/articles/PMC9247944/ /pubmed/35778499 http://dx.doi.org/10.1038/s41390-022-02162-0 Text en © The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Wildman, Emily Mickiewicz, Beata Vogel, Hans J. Thompson, Graham C. Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review |
title | Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review |
title_full | Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review |
title_fullStr | Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review |
title_full_unstemmed | Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review |
title_short | Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review |
title_sort | metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247944/ https://www.ncbi.nlm.nih.gov/pubmed/35778499 http://dx.doi.org/10.1038/s41390-022-02162-0 |
work_keys_str_mv | AT wildmanemily metabolomicsinpediatriclowerrespiratorytractinfectionsandsepsisaliteraturereview AT mickiewiczbeata metabolomicsinpediatriclowerrespiratorytractinfectionsandsepsisaliteraturereview AT vogelhansj metabolomicsinpediatriclowerrespiratorytractinfectionsandsepsisaliteraturereview AT thompsongrahamc metabolomicsinpediatriclowerrespiratorytractinfectionsandsepsisaliteraturereview |