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Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review

ABSTRACT: Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in children. The ability of healthcare providers to diagnose and prognose LRTIs in the pediatric population remains a challenge, as children can present with similar clinical features regardless of th...

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Autores principales: Wildman, Emily, Mickiewicz, Beata, Vogel, Hans J., Thompson, Graham C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247944/
https://www.ncbi.nlm.nih.gov/pubmed/35778499
http://dx.doi.org/10.1038/s41390-022-02162-0
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author Wildman, Emily
Mickiewicz, Beata
Vogel, Hans J.
Thompson, Graham C.
author_facet Wildman, Emily
Mickiewicz, Beata
Vogel, Hans J.
Thompson, Graham C.
author_sort Wildman, Emily
collection PubMed
description ABSTRACT: Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in children. The ability of healthcare providers to diagnose and prognose LRTIs in the pediatric population remains a challenge, as children can present with similar clinical features regardless of the underlying pathogen or ultimate severity. Metabolomics, the large-scale analysis of metabolites and metabolic pathways offers new tools and insights that may aid in diagnosing and predicting the outcomes of LRTIs in children. This review highlights the latest literature on the clinical utility of metabolomics in providing care for children with bronchiolitis, pneumonia, COVID-19, and sepsis. IMPACT: This article summarizes current metabolomics approaches to diagnosing and predicting the course of pediatric lower respiratory infections. This article highlights the limitations to current metabolomics research and highlights future directions for the field.
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spelling pubmed-92479442022-07-01 Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review Wildman, Emily Mickiewicz, Beata Vogel, Hans J. Thompson, Graham C. Pediatr Res Review Article ABSTRACT: Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in children. The ability of healthcare providers to diagnose and prognose LRTIs in the pediatric population remains a challenge, as children can present with similar clinical features regardless of the underlying pathogen or ultimate severity. Metabolomics, the large-scale analysis of metabolites and metabolic pathways offers new tools and insights that may aid in diagnosing and predicting the outcomes of LRTIs in children. This review highlights the latest literature on the clinical utility of metabolomics in providing care for children with bronchiolitis, pneumonia, COVID-19, and sepsis. IMPACT: This article summarizes current metabolomics approaches to diagnosing and predicting the course of pediatric lower respiratory infections. This article highlights the limitations to current metabolomics research and highlights future directions for the field. Nature Publishing Group US 2022-07-01 2023 /pmc/articles/PMC9247944/ /pubmed/35778499 http://dx.doi.org/10.1038/s41390-022-02162-0 Text en © The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Wildman, Emily
Mickiewicz, Beata
Vogel, Hans J.
Thompson, Graham C.
Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review
title Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review
title_full Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review
title_fullStr Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review
title_full_unstemmed Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review
title_short Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review
title_sort metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247944/
https://www.ncbi.nlm.nih.gov/pubmed/35778499
http://dx.doi.org/10.1038/s41390-022-02162-0
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