Cs(2)CO(3) catalyzed direct aza-Michael addition of azoles to α,β-unsaturated malonates

A highly efficient method for the synthesis of azole derivatives via a direct aza-Michael addition of azoles to α,β-unsaturated malonates using Cs(2)CO(3) as a catalyst, has been successfully developed. A series of azole derivatives have been obtained in up to 94% yield and the reaction could be amp...

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Detalles Bibliográficos
Autores principales: Jiang, Zi-Yu, Huang, Zhe-Yao, Yang, Hong, Zhou, Lin, Li, Qing-Han, Zhao, Zhi-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248005/
https://www.ncbi.nlm.nih.gov/pubmed/35865588
http://dx.doi.org/10.1039/d2ra02314h
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author Jiang, Zi-Yu
Huang, Zhe-Yao
Yang, Hong
Zhou, Lin
Li, Qing-Han
Zhao, Zhi-Gang
author_facet Jiang, Zi-Yu
Huang, Zhe-Yao
Yang, Hong
Zhou, Lin
Li, Qing-Han
Zhao, Zhi-Gang
author_sort Jiang, Zi-Yu
collection PubMed
description A highly efficient method for the synthesis of azole derivatives via a direct aza-Michael addition of azoles to α,β-unsaturated malonates using Cs(2)CO(3) as a catalyst, has been successfully developed. A series of azole derivatives have been obtained in up to 94% yield and the reaction could be amplified to gram scale in excellent yield in the presence of 10 mol% of Cs(2)CO(3).
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spelling pubmed-92480052022-07-20 Cs(2)CO(3) catalyzed direct aza-Michael addition of azoles to α,β-unsaturated malonates Jiang, Zi-Yu Huang, Zhe-Yao Yang, Hong Zhou, Lin Li, Qing-Han Zhao, Zhi-Gang RSC Adv Chemistry A highly efficient method for the synthesis of azole derivatives via a direct aza-Michael addition of azoles to α,β-unsaturated malonates using Cs(2)CO(3) as a catalyst, has been successfully developed. A series of azole derivatives have been obtained in up to 94% yield and the reaction could be amplified to gram scale in excellent yield in the presence of 10 mol% of Cs(2)CO(3). The Royal Society of Chemistry 2022-07-01 /pmc/articles/PMC9248005/ /pubmed/35865588 http://dx.doi.org/10.1039/d2ra02314h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Jiang, Zi-Yu
Huang, Zhe-Yao
Yang, Hong
Zhou, Lin
Li, Qing-Han
Zhao, Zhi-Gang
Cs(2)CO(3) catalyzed direct aza-Michael addition of azoles to α,β-unsaturated malonates
title Cs(2)CO(3) catalyzed direct aza-Michael addition of azoles to α,β-unsaturated malonates
title_full Cs(2)CO(3) catalyzed direct aza-Michael addition of azoles to α,β-unsaturated malonates
title_fullStr Cs(2)CO(3) catalyzed direct aza-Michael addition of azoles to α,β-unsaturated malonates
title_full_unstemmed Cs(2)CO(3) catalyzed direct aza-Michael addition of azoles to α,β-unsaturated malonates
title_short Cs(2)CO(3) catalyzed direct aza-Michael addition of azoles to α,β-unsaturated malonates
title_sort cs(2)co(3) catalyzed direct aza-michael addition of azoles to α,β-unsaturated malonates
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248005/
https://www.ncbi.nlm.nih.gov/pubmed/35865588
http://dx.doi.org/10.1039/d2ra02314h
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