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Mechanistic Studies of a Skatole-Forming Glycyl Radical Enzyme Suggest Reaction Initiation via Hydrogen Atom Transfer

[Image: see text] Gut microbial decarboxylation of amino acid-derived arylacetates is a chemically challenging enzymatic transformation which generates small molecules that impact host physiology. The glycyl radical enzyme (GRE) indoleacetate decarboxylase from Olsenella uli (Ou IAD) performs the no...

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Detalles Bibliográficos
Autores principales:	Fu, Beverly, Nazemi, Azadeh, Levin, Benjamin J., Yang, Zhongyue, Kulik, Heather J., Balskus, Emily P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248008/ https://www.ncbi.nlm.nih.gov/pubmed/35704859 http://dx.doi.org/10.1021/jacs.1c13580

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