Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here...

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Autores principales: La Rose, Anouk M., Groenen, Anouk G., Halmos, Benedek, Bazioti, Venetia, Rutten, Martijn G.S., Krishnamurthy, Kishore A., Koster, Mirjam H., Kloosterhuis, Niels J., Smit, Marieke, Havinga, Rick, Mithieux, Gilles, Rajas, Fabienne, Kuipers, Folkert, Oosterveer, Maaike H., Westerterp, Marit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248218/
https://www.ncbi.nlm.nih.gov/pubmed/35782606
http://dx.doi.org/10.1016/j.ymgmr.2022.100872
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author La Rose, Anouk M.
Groenen, Anouk G.
Halmos, Benedek
Bazioti, Venetia
Rutten, Martijn G.S.
Krishnamurthy, Kishore A.
Koster, Mirjam H.
Kloosterhuis, Niels J.
Smit, Marieke
Havinga, Rick
Mithieux, Gilles
Rajas, Fabienne
Kuipers, Folkert
Oosterveer, Maaike H.
Westerterp, Marit
author_facet La Rose, Anouk M.
Groenen, Anouk G.
Halmos, Benedek
Bazioti, Venetia
Rutten, Martijn G.S.
Krishnamurthy, Kishore A.
Koster, Mirjam H.
Kloosterhuis, Niels J.
Smit, Marieke
Havinga, Rick
Mithieux, Gilles
Rajas, Fabienne
Kuipers, Folkert
Oosterveer, Maaike H.
Westerterp, Marit
author_sort La Rose, Anouk M.
collection PubMed
description Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.
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spelling pubmed-92482182022-07-02 Increased atherosclerosis in a mouse model of glycogen storage disease type 1a La Rose, Anouk M. Groenen, Anouk G. Halmos, Benedek Bazioti, Venetia Rutten, Martijn G.S. Krishnamurthy, Kishore A. Koster, Mirjam H. Kloosterhuis, Niels J. Smit, Marieke Havinga, Rick Mithieux, Gilles Rajas, Fabienne Kuipers, Folkert Oosterveer, Maaike H. Westerterp, Marit Mol Genet Metab Rep Short Communication Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort. Elsevier 2022-04-21 /pmc/articles/PMC9248218/ /pubmed/35782606 http://dx.doi.org/10.1016/j.ymgmr.2022.100872 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short Communication
La Rose, Anouk M.
Groenen, Anouk G.
Halmos, Benedek
Bazioti, Venetia
Rutten, Martijn G.S.
Krishnamurthy, Kishore A.
Koster, Mirjam H.
Kloosterhuis, Niels J.
Smit, Marieke
Havinga, Rick
Mithieux, Gilles
Rajas, Fabienne
Kuipers, Folkert
Oosterveer, Maaike H.
Westerterp, Marit
Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
title Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
title_full Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
title_fullStr Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
title_full_unstemmed Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
title_short Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
title_sort increased atherosclerosis in a mouse model of glycogen storage disease type 1a
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248218/
https://www.ncbi.nlm.nih.gov/pubmed/35782606
http://dx.doi.org/10.1016/j.ymgmr.2022.100872
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