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White matter tract strength correlates with therapy outcome in persistent developmental stuttering
Persistent stuttering is a prevalent neurodevelopmental speech disorder, which presents with involuntary speech blocks, sound and syllable repetitions, and sound prolongations. Affected individuals often struggle with negative feelings, elevated anxiety, and low self‐esteem. Neuroimaging studies fre...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248304/ https://www.ncbi.nlm.nih.gov/pubmed/35415866 http://dx.doi.org/10.1002/hbm.25853 |
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author | Neef, Nicole E. Korzeczek, Alexandra Primaßin, Annika Wolff von Gudenberg, Alexander Dechent, Peter Riedel, Christian Heiner Paulus, Walter Sommer, Martin |
author_facet | Neef, Nicole E. Korzeczek, Alexandra Primaßin, Annika Wolff von Gudenberg, Alexander Dechent, Peter Riedel, Christian Heiner Paulus, Walter Sommer, Martin |
author_sort | Neef, Nicole E. |
collection | PubMed |
description | Persistent stuttering is a prevalent neurodevelopmental speech disorder, which presents with involuntary speech blocks, sound and syllable repetitions, and sound prolongations. Affected individuals often struggle with negative feelings, elevated anxiety, and low self‐esteem. Neuroimaging studies frequently link persistent stuttering with cortical alterations and dysfunctional cortico‐basal ganglia‐thalamocortical loops; dMRI data also point toward connectivity changes of the superior longitudinal fasciculus (SLF) and the frontal aslant tract (FAT). Both tracts are involved in speech and language functions, and the FAT also supports inhibitory control and conflict monitoring. Whether the two tracts are involved in therapy‐associated improvements and how they relate to therapeutic outcomes is currently unknown. Here, we analyzed dMRI data of 22 patients who participated in a fluency‐shaping program, 18 patients not participating in therapy, and 27 fluent control participants, measured 1 year apart. We used diffusion tractography to segment the SLF and FAT bilaterally and to quantify their microstructural properties before and after a fluency‐shaping program. Participants learned to speak with soft articulation, pitch, and voicing during a 2‐week on‐site boot camp and computer‐assisted biofeedback‐based daily training for 1 year. Therapy had no impact on the microstructural properties of the two tracts. Yet, after therapy, stuttering severity correlated positively with left SLF fractional anisotropy, whereas relief from the social–emotional burden to stutter correlated negatively with right FAT fractional anisotropy. Thus, posttreatment, speech motor performance relates to the left dorsal stream, while the experience of the adverse impact of stuttering relates to the structure recently associated with conflict monitoring and action inhibition. |
format | Online Article Text |
id | pubmed-9248304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92483042022-07-05 White matter tract strength correlates with therapy outcome in persistent developmental stuttering Neef, Nicole E. Korzeczek, Alexandra Primaßin, Annika Wolff von Gudenberg, Alexander Dechent, Peter Riedel, Christian Heiner Paulus, Walter Sommer, Martin Hum Brain Mapp Research Articles Persistent stuttering is a prevalent neurodevelopmental speech disorder, which presents with involuntary speech blocks, sound and syllable repetitions, and sound prolongations. Affected individuals often struggle with negative feelings, elevated anxiety, and low self‐esteem. Neuroimaging studies frequently link persistent stuttering with cortical alterations and dysfunctional cortico‐basal ganglia‐thalamocortical loops; dMRI data also point toward connectivity changes of the superior longitudinal fasciculus (SLF) and the frontal aslant tract (FAT). Both tracts are involved in speech and language functions, and the FAT also supports inhibitory control and conflict monitoring. Whether the two tracts are involved in therapy‐associated improvements and how they relate to therapeutic outcomes is currently unknown. Here, we analyzed dMRI data of 22 patients who participated in a fluency‐shaping program, 18 patients not participating in therapy, and 27 fluent control participants, measured 1 year apart. We used diffusion tractography to segment the SLF and FAT bilaterally and to quantify their microstructural properties before and after a fluency‐shaping program. Participants learned to speak with soft articulation, pitch, and voicing during a 2‐week on‐site boot camp and computer‐assisted biofeedback‐based daily training for 1 year. Therapy had no impact on the microstructural properties of the two tracts. Yet, after therapy, stuttering severity correlated positively with left SLF fractional anisotropy, whereas relief from the social–emotional burden to stutter correlated negatively with right FAT fractional anisotropy. Thus, posttreatment, speech motor performance relates to the left dorsal stream, while the experience of the adverse impact of stuttering relates to the structure recently associated with conflict monitoring and action inhibition. John Wiley & Sons, Inc. 2022-04-12 /pmc/articles/PMC9248304/ /pubmed/35415866 http://dx.doi.org/10.1002/hbm.25853 Text en © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Neef, Nicole E. Korzeczek, Alexandra Primaßin, Annika Wolff von Gudenberg, Alexander Dechent, Peter Riedel, Christian Heiner Paulus, Walter Sommer, Martin White matter tract strength correlates with therapy outcome in persistent developmental stuttering |
title | White matter tract strength correlates with therapy outcome in persistent developmental stuttering |
title_full | White matter tract strength correlates with therapy outcome in persistent developmental stuttering |
title_fullStr | White matter tract strength correlates with therapy outcome in persistent developmental stuttering |
title_full_unstemmed | White matter tract strength correlates with therapy outcome in persistent developmental stuttering |
title_short | White matter tract strength correlates with therapy outcome in persistent developmental stuttering |
title_sort | white matter tract strength correlates with therapy outcome in persistent developmental stuttering |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248304/ https://www.ncbi.nlm.nih.gov/pubmed/35415866 http://dx.doi.org/10.1002/hbm.25853 |
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