Mutation‐related magnetization‐transfer, not axon density, drives white matter differences in premanifest Huntington disease: Evidence from in vivo ultra‐strong gradient MRI

White matter (WM) alterations have been observed in Huntington disease (HD) but their role in the disease‐pathophysiology remains unknown. We assessed WM changes in premanifest HD by exploiting ultra‐strong‐gradient magnetic resonance imaging (MRI). This allowed to separately quantify magnetization...

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Detalles Bibliográficos
Autores principales: Casella, Chiara, Chamberland, Maxime, Laguna, Pedro L., Parker, Greg D., Rosser, Anne E., Coulthard, Elizabeth, Rickards, Hugh, Berry, Samuel C., Jones, Derek K., Metzler‐Baddeley, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248323/
https://www.ncbi.nlm.nih.gov/pubmed/35396899
http://dx.doi.org/10.1002/hbm.25859

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