Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant

BACKGROUND: Diffuse midline gliomas (DMG) H3K27M-mutant, including diffuse intrinsic pontine glioma (DIPG), are pediatric brain tumors associated with grim prognosis. Although GD2-CAR T-cells demonstrated significant anti-tumor activity against DMG H3K27M-mutant in vivo, a multimodal approach may be...

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Detalles Bibliográficos
Autores principales: de Billy, Emmanuel, Pellegrino, Marsha, Orlando, Domenico, Pericoli, Giulia, Ferretti, Roberta, Businaro, Pietro, Ajmone-Cat, Maria Antonietta, Rossi, Sabrina, Petrilli, Lucia Lisa, Maestro, Nicola, Diomedi-Camassei, Francesca, Pezzullo, Marco, De Stefanis, Cristiano, Bencivenga, Paola, Palma, Alessia, Rota, Rossella, Del Bufalo, Francesca, Massimi, Luca, Weber, Gerrit, Jones, Chris, Carai, Andrea, Caruso, Simona, De Angelis, Biagio, Caruana, Ignazio, Quintarelli, Concetta, Mastronuzzi, Angela, Locatelli, Franco, Vinci, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Pediatric Neuro-Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248389/
https://www.ncbi.nlm.nih.gov/pubmed/34964902
http://dx.doi.org/10.1093/neuonc/noab300

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