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Evaluation of dose, volume, and outcome in children with localized, intracranial ependymoma treated with proton therapy within the prospective KiProReg Study
BACKGROUND: Radiotherapy (RT) of ependymoma in children is an important part of the interdisciplinary treatment concept. However, feasibility and dose concepts are still under investigation, particularly in very young children. The aim of this study was to evaluate the standard dose and volume of pr...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248402/ https://www.ncbi.nlm.nih.gov/pubmed/34964901 http://dx.doi.org/10.1093/neuonc/noab301 |
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author | Peters, Sarah Merta, Julien Schmidt, Laura Jazmati, Danny Kramer, Paul-Heinz Blase, Cristoph Tippelt, Stephan Fleischhack, Gudrun Stock, Annika Bison, Brigitte Rutkowski, Stefan Pietsch, Torsten Kortmann, Rolf-Dieter Timmermann, Beate |
author_facet | Peters, Sarah Merta, Julien Schmidt, Laura Jazmati, Danny Kramer, Paul-Heinz Blase, Cristoph Tippelt, Stephan Fleischhack, Gudrun Stock, Annika Bison, Brigitte Rutkowski, Stefan Pietsch, Torsten Kortmann, Rolf-Dieter Timmermann, Beate |
author_sort | Peters, Sarah |
collection | PubMed |
description | BACKGROUND: Radiotherapy (RT) of ependymoma in children is an important part of the interdisciplinary treatment concept. However, feasibility and dose concepts are still under investigation, particularly in very young children. The aim of this study was to evaluate the standard dose and volume of proton therapy (PT) in children with ependymoma. METHODS: In this analysis, 105 patients with localized, intracranial ependymoma under the age of 18 years treated with PT between 2013 and 2018 were included. Patient characteristics, treatment, outcome, and follow-up data were analyzed using descriptive statistics, Kaplan-Meier, and Cox regression analysis. RESULTS: The median age of patients at PT was 2.8 years (0.9-17.0 years). The molecular subgroup analysis was performed in a subset of 50 patients (37 EP-PFA, 2 EP-PFB, 7 EP-RELA, 2 EP-YAP, 2 NEC [not elsewhere classified]). The median total dose was 59.4 Gy (54.0-62.0 Gy). The median follow-up time was 1.9 years. The estimated 3-year overall survival (OS), local control (LC), and progression-free survival (PFS) rates were 93.7%, 74.1%, and 55.6%, respectively. Within univariable analysis, female gender and lower dose had a positive impact on OS, whereas age ≥4 years had a negative impact on OS and PT given after progression had a negative impact on PFS. In the multivariable analysis, multiple tumor surgeries were associated with lower PFS. New ≥3° late toxicities occurred in 11 patients. CONCLUSION: For children with localized ependymoma, PT was effective and well tolerable. Multiple surgeries showed a negative impact on PFS. |
format | Online Article Text |
id | pubmed-9248402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-92484022022-07-05 Evaluation of dose, volume, and outcome in children with localized, intracranial ependymoma treated with proton therapy within the prospective KiProReg Study Peters, Sarah Merta, Julien Schmidt, Laura Jazmati, Danny Kramer, Paul-Heinz Blase, Cristoph Tippelt, Stephan Fleischhack, Gudrun Stock, Annika Bison, Brigitte Rutkowski, Stefan Pietsch, Torsten Kortmann, Rolf-Dieter Timmermann, Beate Neuro Oncol Pediatric Neuro-Oncology BACKGROUND: Radiotherapy (RT) of ependymoma in children is an important part of the interdisciplinary treatment concept. However, feasibility and dose concepts are still under investigation, particularly in very young children. The aim of this study was to evaluate the standard dose and volume of proton therapy (PT) in children with ependymoma. METHODS: In this analysis, 105 patients with localized, intracranial ependymoma under the age of 18 years treated with PT between 2013 and 2018 were included. Patient characteristics, treatment, outcome, and follow-up data were analyzed using descriptive statistics, Kaplan-Meier, and Cox regression analysis. RESULTS: The median age of patients at PT was 2.8 years (0.9-17.0 years). The molecular subgroup analysis was performed in a subset of 50 patients (37 EP-PFA, 2 EP-PFB, 7 EP-RELA, 2 EP-YAP, 2 NEC [not elsewhere classified]). The median total dose was 59.4 Gy (54.0-62.0 Gy). The median follow-up time was 1.9 years. The estimated 3-year overall survival (OS), local control (LC), and progression-free survival (PFS) rates were 93.7%, 74.1%, and 55.6%, respectively. Within univariable analysis, female gender and lower dose had a positive impact on OS, whereas age ≥4 years had a negative impact on OS and PT given after progression had a negative impact on PFS. In the multivariable analysis, multiple tumor surgeries were associated with lower PFS. New ≥3° late toxicities occurred in 11 patients. CONCLUSION: For children with localized ependymoma, PT was effective and well tolerable. Multiple surgeries showed a negative impact on PFS. Oxford University Press 2021-12-29 /pmc/articles/PMC9248402/ /pubmed/34964901 http://dx.doi.org/10.1093/neuonc/noab301 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Pediatric Neuro-Oncology Peters, Sarah Merta, Julien Schmidt, Laura Jazmati, Danny Kramer, Paul-Heinz Blase, Cristoph Tippelt, Stephan Fleischhack, Gudrun Stock, Annika Bison, Brigitte Rutkowski, Stefan Pietsch, Torsten Kortmann, Rolf-Dieter Timmermann, Beate Evaluation of dose, volume, and outcome in children with localized, intracranial ependymoma treated with proton therapy within the prospective KiProReg Study |
title | Evaluation of dose, volume, and outcome in children with localized,
intracranial ependymoma treated with proton therapy within the prospective KiProReg
Study |
title_full | Evaluation of dose, volume, and outcome in children with localized,
intracranial ependymoma treated with proton therapy within the prospective KiProReg
Study |
title_fullStr | Evaluation of dose, volume, and outcome in children with localized,
intracranial ependymoma treated with proton therapy within the prospective KiProReg
Study |
title_full_unstemmed | Evaluation of dose, volume, and outcome in children with localized,
intracranial ependymoma treated with proton therapy within the prospective KiProReg
Study |
title_short | Evaluation of dose, volume, and outcome in children with localized,
intracranial ependymoma treated with proton therapy within the prospective KiProReg
Study |
title_sort | evaluation of dose, volume, and outcome in children with localized,
intracranial ependymoma treated with proton therapy within the prospective kiproreg
study |
topic | Pediatric Neuro-Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248402/ https://www.ncbi.nlm.nih.gov/pubmed/34964901 http://dx.doi.org/10.1093/neuonc/noab301 |
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