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β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes

AIMS/INTRODUCTION: To explore the predicting factors of exercise response (whether the participants converted to diabetes) in elderly patients with prediabetes. MATERIALS AND METHODS: This is a retrospective subgroup analysis of the registered clinical trial with previous publication of the same coh...

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Autores principales: He, Yali, Feng, Yanhong, Shi, Junli, Tang, Hong, Chen, Linhui, Lou, Qingqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248431/
https://www.ncbi.nlm.nih.gov/pubmed/35191202
http://dx.doi.org/10.1111/jdi.13777
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author He, Yali
Feng, Yanhong
Shi, Junli
Tang, Hong
Chen, Linhui
Lou, Qingqing
author_facet He, Yali
Feng, Yanhong
Shi, Junli
Tang, Hong
Chen, Linhui
Lou, Qingqing
author_sort He, Yali
collection PubMed
description AIMS/INTRODUCTION: To explore the predicting factors of exercise response (whether the participants converted to diabetes) in elderly patients with prediabetes. MATERIALS AND METHODS: This is a retrospective subgroup analysis of the registered clinical trial with previous publication of the same cohort. A total of 248 participants with prediabetes were randomized to the aerobic training (n = 83) group, resistance training (n = 82) group and control group (n = 83). The patients who finished the 2‐year exercise intervention were included in this analysis to explore the factors impacting exercise response. RESULTS: A total of 113 patients with prediabetes completed 2 years of exercise, with 56 participants in the aerobic exercise group and 57 in the resistance exercise group. Patients who reversed to normal glucose tolerance, remained in prediabetes and developed diabetes were 18 (15.90%), 70 (62.00%) and 25 (22.10%), respectively. Logistic regression showed that baseline, homeostatic model 2 assessment of β‐cell function (β = −0.143, P = 0.039), hemoglobin A1c (β = 3.301, P = 0.007) and body mass index (β = 0.402, P = 0.012) were related to exercise response, whereas the waist‐to‐hip ratio (β = −3.277, P = 0.693) and types of exercise (β = 1.192, P = 0.093) were not significantly related to exercise response. CONCLUSIONS: Baseline homeostatic model 2 assessment of β‐cell function, hemoglobin A1c and body mass index were the predictors for the response to exercise in elderly patients with prediabetes.
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spelling pubmed-92484312022-07-05 β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes He, Yali Feng, Yanhong Shi, Junli Tang, Hong Chen, Linhui Lou, Qingqing J Diabetes Investig Articles AIMS/INTRODUCTION: To explore the predicting factors of exercise response (whether the participants converted to diabetes) in elderly patients with prediabetes. MATERIALS AND METHODS: This is a retrospective subgroup analysis of the registered clinical trial with previous publication of the same cohort. A total of 248 participants with prediabetes were randomized to the aerobic training (n = 83) group, resistance training (n = 82) group and control group (n = 83). The patients who finished the 2‐year exercise intervention were included in this analysis to explore the factors impacting exercise response. RESULTS: A total of 113 patients with prediabetes completed 2 years of exercise, with 56 participants in the aerobic exercise group and 57 in the resistance exercise group. Patients who reversed to normal glucose tolerance, remained in prediabetes and developed diabetes were 18 (15.90%), 70 (62.00%) and 25 (22.10%), respectively. Logistic regression showed that baseline, homeostatic model 2 assessment of β‐cell function (β = −0.143, P = 0.039), hemoglobin A1c (β = 3.301, P = 0.007) and body mass index (β = 0.402, P = 0.012) were related to exercise response, whereas the waist‐to‐hip ratio (β = −3.277, P = 0.693) and types of exercise (β = 1.192, P = 0.093) were not significantly related to exercise response. CONCLUSIONS: Baseline homeostatic model 2 assessment of β‐cell function, hemoglobin A1c and body mass index were the predictors for the response to exercise in elderly patients with prediabetes. John Wiley and Sons Inc. 2022-06-20 2022-07 /pmc/articles/PMC9248431/ /pubmed/35191202 http://dx.doi.org/10.1111/jdi.13777 Text en © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Articles
He, Yali
Feng, Yanhong
Shi, Junli
Tang, Hong
Chen, Linhui
Lou, Qingqing
β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes
title β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes
title_full β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes
title_fullStr β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes
title_full_unstemmed β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes
title_short β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes
title_sort β‐cell function and body mass index are predictors of exercise response in elderly patients with prediabetes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248431/
https://www.ncbi.nlm.nih.gov/pubmed/35191202
http://dx.doi.org/10.1111/jdi.13777
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