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Dual Role of Indoles Derived From Intestinal Microbiota on Human Health
Endogenous indole and its derivatives (indoles), considered as promising N-substituted heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and exhibit a range of biological activities. Recent studies indicate that indoles contribute to maintaining the biological bar...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248744/ https://www.ncbi.nlm.nih.gov/pubmed/35784338 http://dx.doi.org/10.3389/fimmu.2022.903526 |
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author | Ye, Xuewei Li, Haiyi Anjum, Komal Zhong, Xinye Miao, Shuping Zheng, Guowan Liu, Wei Li, Lanjuan |
author_facet | Ye, Xuewei Li, Haiyi Anjum, Komal Zhong, Xinye Miao, Shuping Zheng, Guowan Liu, Wei Li, Lanjuan |
author_sort | Ye, Xuewei |
collection | PubMed |
description | Endogenous indole and its derivatives (indoles), considered as promising N-substituted heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and exhibit a range of biological activities. Recent studies indicate that indoles contribute to maintaining the biological barrier of the human intestine, which exert the anti-inflammatory activities mainly through activating AhR and PXR receptors to affect the immune system’s function, significantly improving intestinal health (inflammatory bowel disease, hemorrhagic colitis, colorectal cancer) and further promote human health (diabetes mellitus, central system inflammation, and vascular regulation). However, the revealed toxic influences cannot be ignored. Indoxyl sulfate, an indole derivative, performs nephrotoxicity and cardiovascular toxicity. We addressed the interaction between indoles and intestinal microbiota and the indoles’ effects on human health as double-edged swords. This review provides scientific bases for the correlation of indoles with diseases moreover highlights several directions for subsequent indoles-related studies. |
format | Online Article Text |
id | pubmed-9248744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92487442022-07-02 Dual Role of Indoles Derived From Intestinal Microbiota on Human Health Ye, Xuewei Li, Haiyi Anjum, Komal Zhong, Xinye Miao, Shuping Zheng, Guowan Liu, Wei Li, Lanjuan Front Immunol Immunology Endogenous indole and its derivatives (indoles), considered as promising N-substituted heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and exhibit a range of biological activities. Recent studies indicate that indoles contribute to maintaining the biological barrier of the human intestine, which exert the anti-inflammatory activities mainly through activating AhR and PXR receptors to affect the immune system’s function, significantly improving intestinal health (inflammatory bowel disease, hemorrhagic colitis, colorectal cancer) and further promote human health (diabetes mellitus, central system inflammation, and vascular regulation). However, the revealed toxic influences cannot be ignored. Indoxyl sulfate, an indole derivative, performs nephrotoxicity and cardiovascular toxicity. We addressed the interaction between indoles and intestinal microbiota and the indoles’ effects on human health as double-edged swords. This review provides scientific bases for the correlation of indoles with diseases moreover highlights several directions for subsequent indoles-related studies. Frontiers Media S.A. 2022-06-17 /pmc/articles/PMC9248744/ /pubmed/35784338 http://dx.doi.org/10.3389/fimmu.2022.903526 Text en Copyright © 2022 Ye, Li, Anjum, Zhong, Miao, Zheng, Liu and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ye, Xuewei Li, Haiyi Anjum, Komal Zhong, Xinye Miao, Shuping Zheng, Guowan Liu, Wei Li, Lanjuan Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
title | Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
title_full | Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
title_fullStr | Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
title_full_unstemmed | Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
title_short | Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
title_sort | dual role of indoles derived from intestinal microbiota on human health |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248744/ https://www.ncbi.nlm.nih.gov/pubmed/35784338 http://dx.doi.org/10.3389/fimmu.2022.903526 |
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