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An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli

Colistin, the last resort for multidrug and extensively drug-resistant bacterial infection treatment, was reintroduced after being avoided in clinical settings from the 1970s to the 1990s because of its high toxicity. Colistin is considered a crucial treatment option for Acinetobacter baumannii and...

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Autores principales: Khuntayaporn, Piyatip, Thirapanmethee, Krit, Chomnawang, Mullika Traidej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248837/
https://www.ncbi.nlm.nih.gov/pubmed/35782127
http://dx.doi.org/10.3389/fcimb.2022.882236
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author Khuntayaporn, Piyatip
Thirapanmethee, Krit
Chomnawang, Mullika Traidej
author_facet Khuntayaporn, Piyatip
Thirapanmethee, Krit
Chomnawang, Mullika Traidej
author_sort Khuntayaporn, Piyatip
collection PubMed
description Colistin, the last resort for multidrug and extensively drug-resistant bacterial infection treatment, was reintroduced after being avoided in clinical settings from the 1970s to the 1990s because of its high toxicity. Colistin is considered a crucial treatment option for Acinetobacter baumannii and Pseudomonas aeruginosa, which are listed as critical priority pathogens for new antibiotics by the World Health Organization. The resistance mechanisms of colistin are considered to be chromosomally encoded, and no horizontal transfer has been reported. Nevertheless, in November 2015, a transmissible resistance mechanism of colistin, called mobile colistin resistance (MCR), was discovered. Up to ten families with MCR and more than 100 variants of Gram-negative bacteria have been reported worldwide. Even though few have been reported from Acinetobacter spp. and Pseudomonas spp., it is important to closely monitor the epidemiology of mcr genes in these pathogens. Therefore, this review focuses on the most recent update on colistin resistance and the epidemiology of mcr genes among non-fermentative Gram-negative bacilli, especially Acinetobacter spp. and P. aeruginosa.
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spelling pubmed-92488372022-07-02 An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli Khuntayaporn, Piyatip Thirapanmethee, Krit Chomnawang, Mullika Traidej Front Cell Infect Microbiol Cellular and Infection Microbiology Colistin, the last resort for multidrug and extensively drug-resistant bacterial infection treatment, was reintroduced after being avoided in clinical settings from the 1970s to the 1990s because of its high toxicity. Colistin is considered a crucial treatment option for Acinetobacter baumannii and Pseudomonas aeruginosa, which are listed as critical priority pathogens for new antibiotics by the World Health Organization. The resistance mechanisms of colistin are considered to be chromosomally encoded, and no horizontal transfer has been reported. Nevertheless, in November 2015, a transmissible resistance mechanism of colistin, called mobile colistin resistance (MCR), was discovered. Up to ten families with MCR and more than 100 variants of Gram-negative bacteria have been reported worldwide. Even though few have been reported from Acinetobacter spp. and Pseudomonas spp., it is important to closely monitor the epidemiology of mcr genes in these pathogens. Therefore, this review focuses on the most recent update on colistin resistance and the epidemiology of mcr genes among non-fermentative Gram-negative bacilli, especially Acinetobacter spp. and P. aeruginosa. Frontiers Media S.A. 2022-06-17 /pmc/articles/PMC9248837/ /pubmed/35782127 http://dx.doi.org/10.3389/fcimb.2022.882236 Text en Copyright © 2022 Khuntayaporn, Thirapanmethee and Chomnawang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Khuntayaporn, Piyatip
Thirapanmethee, Krit
Chomnawang, Mullika Traidej
An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli
title An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli
title_full An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli
title_fullStr An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli
title_full_unstemmed An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli
title_short An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli
title_sort update of mobile colistin resistance in non-fermentative gram-negative bacilli
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248837/
https://www.ncbi.nlm.nih.gov/pubmed/35782127
http://dx.doi.org/10.3389/fcimb.2022.882236
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