Role of Ferroptosis in Fibrotic Diseases

Ferroptosis is a unique and pervasive form of regulated cell death driven by iron-dependent phospholipid peroxidation. It results from disturbed cellular metabolism and imbalanced redox homeostasis and is regulated by various cellular metabolic pathways. Recent preclinical studies have revealed that...

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Detalles Bibliográficos
Autores principales: Zhou, Jian, Tan, Yuan, Wang, Rurong, Li, Xuehan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248952/
https://www.ncbi.nlm.nih.gov/pubmed/35783244
http://dx.doi.org/10.2147/JIR.S358470
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author Zhou, Jian
Tan, Yuan
Wang, Rurong
Li, Xuehan
author_facet Zhou, Jian
Tan, Yuan
Wang, Rurong
Li, Xuehan
author_sort Zhou, Jian
collection PubMed
description Ferroptosis is a unique and pervasive form of regulated cell death driven by iron-dependent phospholipid peroxidation. It results from disturbed cellular metabolism and imbalanced redox homeostasis and is regulated by various cellular metabolic pathways. Recent preclinical studies have revealed that ferroptosis may be an attractive therapeutic target in fibrotic diseases, such as liver fibrosis, pulmonary fibrosis, kidney fibrosis, and myocardial fibrosis. This review summarizes the latest knowledge on the regulatory mechanism of ferroptosis and its roles in fibrotic diseases. These updates may provide a novel perspective for the treatment of fibrotic diseases as well as future research.
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spelling pubmed-92489522022-07-02 Role of Ferroptosis in Fibrotic Diseases Zhou, Jian Tan, Yuan Wang, Rurong Li, Xuehan J Inflamm Res Review Ferroptosis is a unique and pervasive form of regulated cell death driven by iron-dependent phospholipid peroxidation. It results from disturbed cellular metabolism and imbalanced redox homeostasis and is regulated by various cellular metabolic pathways. Recent preclinical studies have revealed that ferroptosis may be an attractive therapeutic target in fibrotic diseases, such as liver fibrosis, pulmonary fibrosis, kidney fibrosis, and myocardial fibrosis. This review summarizes the latest knowledge on the regulatory mechanism of ferroptosis and its roles in fibrotic diseases. These updates may provide a novel perspective for the treatment of fibrotic diseases as well as future research. Dove 2022-06-27 /pmc/articles/PMC9248952/ /pubmed/35783244 http://dx.doi.org/10.2147/JIR.S358470 Text en © 2022 Zhou et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Zhou, Jian
Tan, Yuan
Wang, Rurong
Li, Xuehan
Role of Ferroptosis in Fibrotic Diseases
title Role of Ferroptosis in Fibrotic Diseases
title_full Role of Ferroptosis in Fibrotic Diseases
title_fullStr Role of Ferroptosis in Fibrotic Diseases
title_full_unstemmed Role of Ferroptosis in Fibrotic Diseases
title_short Role of Ferroptosis in Fibrotic Diseases
title_sort role of ferroptosis in fibrotic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248952/
https://www.ncbi.nlm.nih.gov/pubmed/35783244
http://dx.doi.org/10.2147/JIR.S358470
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