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Eculizumab's Unintentional Mayhem: A Systematic Review
Eculizumab, first-line therapy for paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), has infectious side effects in addition to its therapeutic benefits. This study aims to discuss the mechanism of development of infections, prevention, and timely treatment to...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249032/ https://www.ncbi.nlm.nih.gov/pubmed/35784997 http://dx.doi.org/10.7759/cureus.25640 |
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author | Dhanoa, Ravneet K Selvaraj, Ramaneshwar Shoukrie, Shoukrie I Zahra, Anam Malla, Jyothirmai Selvamani, Tharun Yadhav Venugopal, Sathish Hamouda, Ranim K Hamid, Pousette |
author_facet | Dhanoa, Ravneet K Selvaraj, Ramaneshwar Shoukrie, Shoukrie I Zahra, Anam Malla, Jyothirmai Selvamani, Tharun Yadhav Venugopal, Sathish Hamouda, Ranim K Hamid, Pousette |
author_sort | Dhanoa, Ravneet K |
collection | PubMed |
description | Eculizumab, first-line therapy for paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), has infectious side effects in addition to its therapeutic benefits. This study aims to discuss the mechanism of development of infections, prevention, and timely treatment to prevent complications such as septic shock and mortality. The study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist and reporting guidelines for systematic review. Inclusion and exclusion criteria were determined. A total of 10 research papers were extracted after exploring Pubmed and Google Scholar from 2001 to 2021. The New Castle Ottawa Questionnaire for non-randomized clinical trials and the National Institutes of Health (NIH) quality assessment tool for case reports and case series were used to assess the risk of bias. The studies included in this systematic review describe infections with Neisseria meningitidis, Neisseria gonorrhoeae, unusual Neisseria species, Moraxella lacunata, and Pseudomonas aeruginosa. The main goal of this review is to impress upon the seriousness of the infectious complications associated with eculizumab. Health care providers should maintain a high index of suspicion for early identification and treatment. |
format | Online Article Text |
id | pubmed-9249032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-92490322022-07-02 Eculizumab's Unintentional Mayhem: A Systematic Review Dhanoa, Ravneet K Selvaraj, Ramaneshwar Shoukrie, Shoukrie I Zahra, Anam Malla, Jyothirmai Selvamani, Tharun Yadhav Venugopal, Sathish Hamouda, Ranim K Hamid, Pousette Cureus Internal Medicine Eculizumab, first-line therapy for paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), has infectious side effects in addition to its therapeutic benefits. This study aims to discuss the mechanism of development of infections, prevention, and timely treatment to prevent complications such as septic shock and mortality. The study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist and reporting guidelines for systematic review. Inclusion and exclusion criteria were determined. A total of 10 research papers were extracted after exploring Pubmed and Google Scholar from 2001 to 2021. The New Castle Ottawa Questionnaire for non-randomized clinical trials and the National Institutes of Health (NIH) quality assessment tool for case reports and case series were used to assess the risk of bias. The studies included in this systematic review describe infections with Neisseria meningitidis, Neisseria gonorrhoeae, unusual Neisseria species, Moraxella lacunata, and Pseudomonas aeruginosa. The main goal of this review is to impress upon the seriousness of the infectious complications associated with eculizumab. Health care providers should maintain a high index of suspicion for early identification and treatment. Cureus 2022-06-03 /pmc/articles/PMC9249032/ /pubmed/35784997 http://dx.doi.org/10.7759/cureus.25640 Text en Copyright © 2022, Dhanoa et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Dhanoa, Ravneet K Selvaraj, Ramaneshwar Shoukrie, Shoukrie I Zahra, Anam Malla, Jyothirmai Selvamani, Tharun Yadhav Venugopal, Sathish Hamouda, Ranim K Hamid, Pousette Eculizumab's Unintentional Mayhem: A Systematic Review |
title | Eculizumab's Unintentional Mayhem: A Systematic Review |
title_full | Eculizumab's Unintentional Mayhem: A Systematic Review |
title_fullStr | Eculizumab's Unintentional Mayhem: A Systematic Review |
title_full_unstemmed | Eculizumab's Unintentional Mayhem: A Systematic Review |
title_short | Eculizumab's Unintentional Mayhem: A Systematic Review |
title_sort | eculizumab's unintentional mayhem: a systematic review |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249032/ https://www.ncbi.nlm.nih.gov/pubmed/35784997 http://dx.doi.org/10.7759/cureus.25640 |
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