Cargando…

Pause at Your Own Peril: A Case Series on Rebound Pulmonary Hypertension

Severe pulmonary arterial hypertension (PAH) is associated with high morbidity and mortality. Therapeutic approaches for intermediate- and high-risk pulmonary arterial hypertension have now shifted toward initial combination management, often including parenteral epoprostenol and iloprost and early...

Descripción completa

Detalles Bibliográficos
Autores principales: Murali, Sindhubarathi, Khanal, Subrat, Banerjee, Sanchari, Christie, Omari, Ramakrishna, Kartik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249055/
https://www.ncbi.nlm.nih.gov/pubmed/35783883
http://dx.doi.org/10.7759/cureus.25552
_version_ 1784739489366671360
author Murali, Sindhubarathi
Khanal, Subrat
Banerjee, Sanchari
Christie, Omari
Ramakrishna, Kartik
author_facet Murali, Sindhubarathi
Khanal, Subrat
Banerjee, Sanchari
Christie, Omari
Ramakrishna, Kartik
author_sort Murali, Sindhubarathi
collection PubMed
description Severe pulmonary arterial hypertension (PAH) is associated with high morbidity and mortality. Therapeutic approaches for intermediate- and high-risk pulmonary arterial hypertension have now shifted toward initial combination management, often including parenteral epoprostenol and iloprost and early assessment for a lung transplant. After the initiation of therapy, usually various combinations of different classes of medication, it is important to consider the potential interruption in therapy causing rebound PAH. We present two patients recently admitted to our hospital with rebound symptoms after interruption of their pulmonary vasodilator therapy.
format Online
Article
Text
id pubmed-9249055
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-92490552022-07-02 Pause at Your Own Peril: A Case Series on Rebound Pulmonary Hypertension Murali, Sindhubarathi Khanal, Subrat Banerjee, Sanchari Christie, Omari Ramakrishna, Kartik Cureus Internal Medicine Severe pulmonary arterial hypertension (PAH) is associated with high morbidity and mortality. Therapeutic approaches for intermediate- and high-risk pulmonary arterial hypertension have now shifted toward initial combination management, often including parenteral epoprostenol and iloprost and early assessment for a lung transplant. After the initiation of therapy, usually various combinations of different classes of medication, it is important to consider the potential interruption in therapy causing rebound PAH. We present two patients recently admitted to our hospital with rebound symptoms after interruption of their pulmonary vasodilator therapy. Cureus 2022-05-31 /pmc/articles/PMC9249055/ /pubmed/35783883 http://dx.doi.org/10.7759/cureus.25552 Text en Copyright © 2022, Murali et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Murali, Sindhubarathi
Khanal, Subrat
Banerjee, Sanchari
Christie, Omari
Ramakrishna, Kartik
Pause at Your Own Peril: A Case Series on Rebound Pulmonary Hypertension
title Pause at Your Own Peril: A Case Series on Rebound Pulmonary Hypertension
title_full Pause at Your Own Peril: A Case Series on Rebound Pulmonary Hypertension
title_fullStr Pause at Your Own Peril: A Case Series on Rebound Pulmonary Hypertension
title_full_unstemmed Pause at Your Own Peril: A Case Series on Rebound Pulmonary Hypertension
title_short Pause at Your Own Peril: A Case Series on Rebound Pulmonary Hypertension
title_sort pause at your own peril: a case series on rebound pulmonary hypertension
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249055/
https://www.ncbi.nlm.nih.gov/pubmed/35783883
http://dx.doi.org/10.7759/cureus.25552
work_keys_str_mv AT muralisindhubarathi pauseatyourownperilacaseseriesonreboundpulmonaryhypertension
AT khanalsubrat pauseatyourownperilacaseseriesonreboundpulmonaryhypertension
AT banerjeesanchari pauseatyourownperilacaseseriesonreboundpulmonaryhypertension
AT christieomari pauseatyourownperilacaseseriesonreboundpulmonaryhypertension
AT ramakrishnakartik pauseatyourownperilacaseseriesonreboundpulmonaryhypertension