Single-cell RNA-seq of a soft-tissue sarcoma model reveals the critical role of tumor-expressed MIF in shaping macrophage heterogeneity

The standard of care is unsuccessful to treat recurrent and aggressive soft-tissue sarcomas. Interventions aimed at targeting components of the tumor microenvironment have shown promise for many solid tumors yet have been only marginally tested for sarcoma, partly because knowledge of the sarcoma mi...

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Detalles Bibliográficos
Autores principales: Tessaro, Fernando H.G., Ko, Emily Y., De Simone, Marco, Piras, Roberta, Broz, Marina T., Goodridge, Helen S., Balzer, Bonnie, Shiao, Stephen L., Guarnerio, Jlenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249098/
https://www.ncbi.nlm.nih.gov/pubmed/35732118
http://dx.doi.org/10.1016/j.celrep.2022.110977

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