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Functional Definition of Thyroid Hormone Response Elements Based on a Synthetic STARR-seq Screen
When bound to thyroid hormone, the nuclear receptor TRα1 activates the transcription of a number of genes in many cell types. It mainly acts by binding DNA as a heterodimer with retinoid X receptors at specific response elements related to the DR4 consensus sequence. However, the number of DR4-like...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249314/ https://www.ncbi.nlm.nih.gov/pubmed/35678380 http://dx.doi.org/10.1210/endocr/bqac084 |