ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate

This study aimed to elucidate the role of ELF3, an ETS family member in normal prostate growth and prostate cancer. Silencing ELF3 in both benign prostate (BPH‐1) and prostate cancer (PC3) cell lines resulted in decreased colony‐forming ability, inhibition of cell migration and reduced cell viabilit...

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Autores principales: Archer, Leanne K., Frame, Fiona M., Walker, Hannah F., Droop, Alastair P., McDonald, Georgina L. K., Kucko, Samuel, Berney, Daniel M., Mann, Vincent M., Simms, Matthew S., Maitland, Norman J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249341/
https://www.ncbi.nlm.nih.gov/pubmed/35472129
http://dx.doi.org/10.1002/2211-5463.13417
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author Archer, Leanne K.
Frame, Fiona M.
Walker, Hannah F.
Droop, Alastair P.
McDonald, Georgina L. K.
Kucko, Samuel
Berney, Daniel M.
Mann, Vincent M.
Simms, Matthew S.
Maitland, Norman J.
author_facet Archer, Leanne K.
Frame, Fiona M.
Walker, Hannah F.
Droop, Alastair P.
McDonald, Georgina L. K.
Kucko, Samuel
Berney, Daniel M.
Mann, Vincent M.
Simms, Matthew S.
Maitland, Norman J.
author_sort Archer, Leanne K.
collection PubMed
description This study aimed to elucidate the role of ELF3, an ETS family member in normal prostate growth and prostate cancer. Silencing ELF3 in both benign prostate (BPH‐1) and prostate cancer (PC3) cell lines resulted in decreased colony‐forming ability, inhibition of cell migration and reduced cell viability due to cell cycle arrest, establishing ELF3 as a cell cycle regulator. Increased ELF3 expression in more advanced prostate tumours was shown by immunostaining of tissue microarrays and from analysis of gene expression and genetic alteration studies. This study indicates that ELF3 functions not only as a part of normal prostate epithelial growth but also as a potential oncogene in advanced prostate cancers.
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spelling pubmed-92493412022-07-05 ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate Archer, Leanne K. Frame, Fiona M. Walker, Hannah F. Droop, Alastair P. McDonald, Georgina L. K. Kucko, Samuel Berney, Daniel M. Mann, Vincent M. Simms, Matthew S. Maitland, Norman J. FEBS Open Bio Research Articles This study aimed to elucidate the role of ELF3, an ETS family member in normal prostate growth and prostate cancer. Silencing ELF3 in both benign prostate (BPH‐1) and prostate cancer (PC3) cell lines resulted in decreased colony‐forming ability, inhibition of cell migration and reduced cell viability due to cell cycle arrest, establishing ELF3 as a cell cycle regulator. Increased ELF3 expression in more advanced prostate tumours was shown by immunostaining of tissue microarrays and from analysis of gene expression and genetic alteration studies. This study indicates that ELF3 functions not only as a part of normal prostate epithelial growth but also as a potential oncogene in advanced prostate cancers. John Wiley and Sons Inc. 2022-05-06 /pmc/articles/PMC9249341/ /pubmed/35472129 http://dx.doi.org/10.1002/2211-5463.13417 Text en © 2022 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Archer, Leanne K.
Frame, Fiona M.
Walker, Hannah F.
Droop, Alastair P.
McDonald, Georgina L. K.
Kucko, Samuel
Berney, Daniel M.
Mann, Vincent M.
Simms, Matthew S.
Maitland, Norman J.
ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate
title ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate
title_full ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate
title_fullStr ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate
title_full_unstemmed ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate
title_short ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate
title_sort ets transcription factor elf3 (ese‐1) is a cell cycle regulator in benign and malignant prostate
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249341/
https://www.ncbi.nlm.nih.gov/pubmed/35472129
http://dx.doi.org/10.1002/2211-5463.13417
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