Cargando…

The Anti-Tumor Efficacy of Verbascoside on Ovarian Cancer via Facilitating CCN1-AKT/NF-κB Pathway-Mediated M1 Macrophage Polarization

BACKGROUND: Ovarian cancer (OC) is the leading cause of gynecological cancer-related mortality. Verbascoside (VB) is a phenylpropanoid glycoside from Chinese herbs, with anti-tumour activities. This study aimed to investigate the effects and mechanism of VB on OC. METHODS: OC cell lines SKOV3 and A2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Yu, He, Jinying, Zhao, Wenhua, Ma, Yuzhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249354/ https://www.ncbi.nlm.nih.gov/pubmed/35785168 http://dx.doi.org/10.3389/fonc.2022.901922

Ejemplares similares

TPL Inhibits the Invasion and Migration of Drug-Resistant Ovarian Cancer by Targeting the PI3K/AKT/NF-κB-Signaling Pathway to Inhibit the Polarization of M2 TAMs
por: Le, Fuyin, et al.
Publicado: (2021)

Osteoarthritis is Prevented in Rats by Verbascoside via Nuclear Factor kappa B (NF-κB) Pathway Downregulation
por: Ma, Hongbing, et al.
Publicado: (2020)

Macrophage Polarization in the Development and Progression of Ovarian Cancers: An Overview
por: Cheng, Huiyan, et al.
Publicado: (2019)

Synergism and Subadditivity of Verbascoside-Lignans and -Iridoids Binary Mixtures Isolated from Castilleja tenuiflora Benth. on NF-κB/AP-1 Inhibition Activity
por: Arango-De la Pava, Luis David, et al.
Publicado: (2021)

Verbascoside Protects Gingival Cells against High Glucose-Induced Oxidative Stress via PKC/HMGB1/RAGE/NFκB Pathway
por: Hsieh, Pei-Fang, et al.
Publicado: (2021)

LINC00494 Promotes Ovarian Cancer Development and Progression by Modulating NFκB1 and FBXO32
por: Shu, Yang, et al.
Publicado: (2021)

The Neuroprotection of Verbascoside in Alzheimer’s Disease Mediated through Mitigation of Neuroinflammation via Blocking NF-κB-p65 Signaling
por: Chen, Shanshan, et al.
Publicado: (2022)

Exosomal miR-183-5p Shuttled by M2 Polarized Tumor-Associated Macrophage Promotes the Development of Colon Cancer via Targeting THEM4 Mediated PI3K/AKT and NF-κB Pathways
por: Zhang, Shangxin, et al.
Publicado: (2021)

Complete biosynthesis of the phenylethanoid glycoside verbascoside
por: Yang, Yihan, et al.
Publicado: (2023)

Norcantharidin Facilitates LPS-Mediated Immune Responses by Up-Regulation of AKT/NF-κB Signaling in Macrophages
por: Zhao, Qufei, et al.
Publicado: (2012)

CCN1 Promotes Inflammation by Inducing IL-6 Production via α6β1/PI3K/Akt/NF-κB Pathway in Autoimmune Hepatitis
por: Jiang, Renquan, et al.
Publicado: (2022)

Verbascoside alleviates renal fibrosis in unilateral ureteral obstruction rats by inhibiting macrophage infiltration
por: Zhang, Guihua, et al.
Publicado: (2021)

Effects of Acanthus ebracteatus Vahl. extract and verbascoside on human dermal papilla and murine macrophage
por: Wisuitiprot, Vanuchawan, et al.
Publicado: (2022)

Calmodulin 2 Facilitates Angiogenesis and Metastasis of Gastric Cancer via STAT3/HIF-1A/VEGF-A Mediated Macrophage Polarization
por: Mu, Ganggang, et al.
Publicado: (2021)

Interleukin-34-NF-κB signaling aggravates myocardial ischemic/reperfusion injury by facilitating macrophage recruitment and polarization
por: Zhuang, Lingfang, et al.
Publicado: (2023)

CD155 Promotes the Progression of Cervical Cancer Cells Through AKT/mTOR and NF-κB Pathways
por: Liu, Lu, et al.
Publicado: (2021)

Polysaccharides from Citrus grandis associate with luteolin relieves chronic pharyngitis by anti-inflammatory via suppressing NF-κB pathway and the polarization of M1 macrophages
por: Chen, Xiumei, et al.
Publicado: (2018)

lncRNA DCST1-AS1 Facilitates Oral Squamous Cell Carcinoma by Promoting M2 Macrophage Polarization through Activating NF-κB Signaling
por: Ai, Yilong, et al.
Publicado: (2021)

The cytotoxicity and apoptotic effects of verbascoside on breast cancer 4T1 cell line
por: Daneshforouz, Atena, et al.
Publicado: (2021)

C1ql4 regulates breast cancer cell stemness and epithelial-mesenchymal transition through PI3K/AKT/NF-κB signaling pathway
por: Xu, Fan, et al.
Publicado: (2023)

The Overexpression of TGF-β and CCN2 in Intrauterine Adhesions Involves the NF-κB Signaling Pathway
por: Xue, Xiang, et al.
Publicado: (2015)

NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
por: Jayawant, Eleanor, et al.
Publicado: (2023)

The Binding of PD-L1 and Akt Facilitates Glioma Cell Invasion Upon Starvation via Akt/Autophagy/F-Actin Signaling
por: Chen, Ruo Qiao, et al.
Publicado: (2019)

Quantification of verbascoside in medicinal species of Phlomis and their genetic relationships
por: Sarkhail, Parisa, et al.
Publicado: (2014)

Regulation of Macrophage Polarization by miR-449a/Cripto-1-PI3K/AKT/NF-κB Signaling Pathway in Allogeneic Transfusion Mice
por: Wang, Huan, et al.
Publicado: (2023)

Repetitive Low-Level Blast Exposure via Akt/NF-κB Signaling Pathway Mediates the M1 Polarization of Mouse Alveolar Macrophage MH-S Cells
por: Geng, Chenhao, et al.
Publicado: (2023)

Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet’s disease
por: Wu, Xiuhua, et al.
Publicado: (2022)

Ginaton reduces M1-polarized macrophages in hypertensive cardiac remodeling via NF-κB signaling
por: Wang, Jie, et al.
Publicado: (2023)

12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer
por: Liu, Qian, et al.
Publicado: (2018)

PFKFB3 Regulates Chemoresistance, Metastasis and Stemness via IAP Proteins and the NF-κB Signaling Pathway in Ovarian Cancer
por: Jiang, Yu-xin, et al.
Publicado: (2022)

SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-κB pathway
por: Zhou, Bei, et al.
Publicado: (2019)

Aligned electrospun poly(l-lactide) nanofibers facilitate wound healing by inhibiting macrophage M1 polarization via the JAK-STAT and NF-κB pathways
por: Xie, Jian, et al.
Publicado: (2022)

OXCT1 Enhances Gemcitabine Resistance Through NF-κB Pathway in Pancreatic Ductal Adenocarcinoma
por: Ding, Jinsheng, et al.
Publicado: (2021)

The NF-κB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1β
por: Kaler, Pawan, et al.
Publicado: (2009)

Correction: Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behcet’s disease
por: Wu, Xiuhua, et al.
Publicado: (2022)

ALOX5AP Predicts Poor Prognosis by Enhancing M2 Macrophages Polarization and Immunosuppression in Serous Ovarian Cancer Microenvironment
por: Ye, Xiang, et al.
Publicado: (2021)

7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression
por: Wen, Ying, et al.
Publicado: (2020)

Glycyrrhizic Acid Promotes M1 Macrophage Polarization in Murine Bone Marrow-Derived Macrophages Associated with the Activation of JNK and NF-κB
por: Mao, Yulong, et al.
Publicado: (2015)

In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes
por: Reid, Anna-Mari, et al.
Publicado: (2019)

Verbascoside Protects Pancreatic β-Cells against ER-Stress
por: Galli, Alessandra, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0r22aipgn90178avsegtiik9d8