Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

Antibiotics of the β-lactam (penicillin) family inactivate target enzymes called D,D-transpeptidases or penicillin-binding proteins (PBPs) that catalyze the last cross-linking step of peptidoglycan synthesis. The resulting net-like macromolecule is the essential component of bacterial cell walls tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Atze, Heiner, Liang, Yucheng, Hugonnet, Jean-Emmanuel, Gutierrez, Arnaud, Rusconi, Filippo, Arthur, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249393/
https://www.ncbi.nlm.nih.gov/pubmed/35678393
http://dx.doi.org/10.7554/eLife.72863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249393/
https://www.ncbi.nlm.nih.gov/pubmed/35678393
http://dx.doi.org/10.7554/eLife.72863

Ejemplares similares