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Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

Antibiotics of the β-lactam (penicillin) family inactivate target enzymes called D,D-transpeptidases or penicillin-binding proteins (PBPs) that catalyze the last cross-linking step of peptidoglycan synthesis. The resulting net-like macromolecule is the essential component of bacterial cell walls tha...

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Detalles Bibliográficos
Autores principales:	Atze, Heiner, Liang, Yucheng, Hugonnet, Jean-Emmanuel, Gutierrez, Arnaud, Rusconi, Filippo, Arthur, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Microbiology and Infectious Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249393/ https://www.ncbi.nlm.nih.gov/pubmed/35678393 http://dx.doi.org/10.7554/eLife.72863

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