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Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture
INTRODUCTION: Modern radiation therapy has become an effective method to treat and monitor tumour growth in cancer patients. It has proved to be a successful way to minimise mortality rates. However, the adverse effects of radiation have been historical evidence in the clinical environment involving...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249517/ https://www.ncbi.nlm.nih.gov/pubmed/35782085 http://dx.doi.org/10.1155/2022/9890633 |
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author | Bakar, Ayuni Amalina Abu Mohamad, Noor Shafini Mahmud, Mohd Hafizi Razak, Hairil Rashmizal Abdul Sudin, Ann Erynna Lema Thomas Shuib, Solehuddin |
author_facet | Bakar, Ayuni Amalina Abu Mohamad, Noor Shafini Mahmud, Mohd Hafizi Razak, Hairil Rashmizal Abdul Sudin, Ann Erynna Lema Thomas Shuib, Solehuddin |
author_sort | Bakar, Ayuni Amalina Abu |
collection | PubMed |
description | INTRODUCTION: Modern radiation therapy has become an effective method to treat and monitor tumour growth in cancer patients. It has proved to be a successful way to minimise mortality rates. However, the adverse effects of radiation have been historical evidence in the clinical environment involving diminishing the quality and density of bone and causing fragility fracture to the bone in the long run. This systematic review was aimed at identifying and evaluating the effects of irradiation on morphology and mechanical properties of murine model bone in previous publications. METHODS: A systematic literature review was undertaken following the Preferred Reporting Items for Systemic Reviews and Meta-analysis (PRISMA) guidelines. A comprehensive literature search was performed using Scopus, Web of Science, and Science Direct databases (English only studies published between 2015 and 2020). The selected studies were evaluated according to three criteria: (1) criteria for study sample selection; (2) criteria for methodological procedures; and (3) criteria for detection and evaluation. RESULTS: The initial search strategy identified 1408 related studies, 8 of were included based on inclusion and exclusion criteria. This review revealed an association between bone destruction and the magnitude of time and dose postirradiation. We agreed that the effect of radiation on bone morphology and strength primarily is a later stage event but noticeable in both low (1 Gy) and high dose (30 Gy) radiation. Trabecular and cortical bone microstructures were significantly altered at irradiation and contralateral sites. Besides, the mechanical strength was significantly impacted in both shorter and longer periods. CONCLUSION: Overall, the radiotherapy altered bone microstructures and substantially decreases bone mechanical properties. The alteration was related to quantity and the activity of the osteoblast and osteoclast. Early detection of those most at risk for radiation-induced bone alterations could lead to better prophylactic intervention decisions. |
format | Online Article Text |
id | pubmed-9249517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-92495172022-07-02 Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture Bakar, Ayuni Amalina Abu Mohamad, Noor Shafini Mahmud, Mohd Hafizi Razak, Hairil Rashmizal Abdul Sudin, Ann Erynna Lema Thomas Shuib, Solehuddin Biomed Res Int Review Article INTRODUCTION: Modern radiation therapy has become an effective method to treat and monitor tumour growth in cancer patients. It has proved to be a successful way to minimise mortality rates. However, the adverse effects of radiation have been historical evidence in the clinical environment involving diminishing the quality and density of bone and causing fragility fracture to the bone in the long run. This systematic review was aimed at identifying and evaluating the effects of irradiation on morphology and mechanical properties of murine model bone in previous publications. METHODS: A systematic literature review was undertaken following the Preferred Reporting Items for Systemic Reviews and Meta-analysis (PRISMA) guidelines. A comprehensive literature search was performed using Scopus, Web of Science, and Science Direct databases (English only studies published between 2015 and 2020). The selected studies were evaluated according to three criteria: (1) criteria for study sample selection; (2) criteria for methodological procedures; and (3) criteria for detection and evaluation. RESULTS: The initial search strategy identified 1408 related studies, 8 of were included based on inclusion and exclusion criteria. This review revealed an association between bone destruction and the magnitude of time and dose postirradiation. We agreed that the effect of radiation on bone morphology and strength primarily is a later stage event but noticeable in both low (1 Gy) and high dose (30 Gy) radiation. Trabecular and cortical bone microstructures were significantly altered at irradiation and contralateral sites. Besides, the mechanical strength was significantly impacted in both shorter and longer periods. CONCLUSION: Overall, the radiotherapy altered bone microstructures and substantially decreases bone mechanical properties. The alteration was related to quantity and the activity of the osteoblast and osteoclast. Early detection of those most at risk for radiation-induced bone alterations could lead to better prophylactic intervention decisions. Hindawi 2022-06-06 /pmc/articles/PMC9249517/ /pubmed/35782085 http://dx.doi.org/10.1155/2022/9890633 Text en Copyright © 2022 Ayuni Amalina Abu Bakar et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bakar, Ayuni Amalina Abu Mohamad, Noor Shafini Mahmud, Mohd Hafizi Razak, Hairil Rashmizal Abdul Sudin, Ann Erynna Lema Thomas Shuib, Solehuddin Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture |
title | Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture |
title_full | Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture |
title_fullStr | Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture |
title_full_unstemmed | Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture |
title_short | Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture |
title_sort | systematic review on multilevel analysis of radiation effects on bone microarchitecture |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249517/ https://www.ncbi.nlm.nih.gov/pubmed/35782085 http://dx.doi.org/10.1155/2022/9890633 |
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