Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment

Merkel cell carcinoma (MCC) is an aggressive malignancy with neuroendocrine (NE) features, limited treatment options, and a lack of druggable targets. There is no reported involvement of the MUC1-C oncogenic protein in MCC progression. We show here that MUC1-C is broadly expressed in MCCs and at hig...

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Detalles Bibliográficos
Autores principales: Morimoto, Yoshihiro, Fushimi, Atsushi, Yamashita, Nami, Hagiwara, Masayuki, Bhattacharya, Atrayee, Cheng, Jingwei, Frost, Thomas C., Ahmad, Rehan, Daimon, Tatsuaki, Huang, Lei, Hata, Tsuyoshi, Takahashi, Hidekazu, Yamamoto, Masaaki, Suzuki, Yozo, DeCaprio, James A., Kufe, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249628/
https://www.ncbi.nlm.nih.gov/pubmed/35688945
http://dx.doi.org/10.1038/s41388-022-02361-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249628/
https://www.ncbi.nlm.nih.gov/pubmed/35688945
http://dx.doi.org/10.1038/s41388-022-02361-3

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