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Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor

INTRODUCTION: Metastasis to the bone marrow is rare in testicular germ cell tumor patients. We report a case of a patient with a non‐seminomatous testicular germ cell tumor who presented with bone marrow metastases after intensive chemotherapy. CASE PRESENTATION: A 36‐year‐old man was admitted to th...

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Autores principales: Ueda, Takashi, Takada, Ippei, Shimizu, Teruki, Ito, Saya, Fujihara, Atsuko, Shiraishi, Takumi, Nakamura, Terukazu, Ukimura, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249660/
https://www.ncbi.nlm.nih.gov/pubmed/35800110
http://dx.doi.org/10.1002/iju5.12446
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author Ueda, Takashi
Takada, Ippei
Shimizu, Teruki
Ito, Saya
Fujihara, Atsuko
Shiraishi, Takumi
Nakamura, Terukazu
Ukimura, Osamu
author_facet Ueda, Takashi
Takada, Ippei
Shimizu, Teruki
Ito, Saya
Fujihara, Atsuko
Shiraishi, Takumi
Nakamura, Terukazu
Ukimura, Osamu
author_sort Ueda, Takashi
collection PubMed
description INTRODUCTION: Metastasis to the bone marrow is rare in testicular germ cell tumor patients. We report a case of a patient with a non‐seminomatous testicular germ cell tumor who presented with bone marrow metastases after intensive chemotherapy. CASE PRESENTATION: A 36‐year‐old man was admitted to the hospital with pancytopenia. Previously, he had received intensive care for an advanced left testicular germ cell tumor. Although multidisciplinary treatments including several regimens of salvage chemotherapy, desperation retroperitoneal lymph node dissection, and focal radiotherapy were performed, the serum tumor marker alfa‐fetoprotein was not normalized and there were no findings of relapse by several imaging modalities. Bone marrow aspirate, conducted to diagnose a cause of pancytopenia, revealed metastatic germ cell tumors in the bone marrow. CONCLUSION: Bone marrow metastasis should be considered as a differential diagnosis in patients with germ cell tumors whose serum tumor makers are not normalized without any radiographic finding of recurrence.
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spelling pubmed-92496602022-07-06 Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor Ueda, Takashi Takada, Ippei Shimizu, Teruki Ito, Saya Fujihara, Atsuko Shiraishi, Takumi Nakamura, Terukazu Ukimura, Osamu IJU Case Rep Case Reports INTRODUCTION: Metastasis to the bone marrow is rare in testicular germ cell tumor patients. We report a case of a patient with a non‐seminomatous testicular germ cell tumor who presented with bone marrow metastases after intensive chemotherapy. CASE PRESENTATION: A 36‐year‐old man was admitted to the hospital with pancytopenia. Previously, he had received intensive care for an advanced left testicular germ cell tumor. Although multidisciplinary treatments including several regimens of salvage chemotherapy, desperation retroperitoneal lymph node dissection, and focal radiotherapy were performed, the serum tumor marker alfa‐fetoprotein was not normalized and there were no findings of relapse by several imaging modalities. Bone marrow aspirate, conducted to diagnose a cause of pancytopenia, revealed metastatic germ cell tumors in the bone marrow. CONCLUSION: Bone marrow metastasis should be considered as a differential diagnosis in patients with germ cell tumors whose serum tumor makers are not normalized without any radiographic finding of recurrence. John Wiley and Sons Inc. 2022-04-10 /pmc/articles/PMC9249660/ /pubmed/35800110 http://dx.doi.org/10.1002/iju5.12446 Text en © 2022 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Ueda, Takashi
Takada, Ippei
Shimizu, Teruki
Ito, Saya
Fujihara, Atsuko
Shiraishi, Takumi
Nakamura, Terukazu
Ukimura, Osamu
Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor
title Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor
title_full Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor
title_fullStr Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor
title_full_unstemmed Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor
title_short Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor
title_sort bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249660/
https://www.ncbi.nlm.nih.gov/pubmed/35800110
http://dx.doi.org/10.1002/iju5.12446
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