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Identification of pyroptosis-related long non-coding RNAs with prognosis and therapy in lung squamous cell carcinoma
Pyroptosis is a type of programmed cell death with an intense inflammatory response. Previous studies have shown that pyroptosis plays an important role in the pathogenesis and progression of lung cancer. However, the prognostic value and drug targets of pyroptosis-related lncRNAs in lung squamous c...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249737/ https://www.ncbi.nlm.nih.gov/pubmed/35778526 http://dx.doi.org/10.1038/s41598-022-15373-6 |
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author | Zhang, Yi Wang, Yuzhi Yin, Xiaoqing Huang, Yi |
author_facet | Zhang, Yi Wang, Yuzhi Yin, Xiaoqing Huang, Yi |
author_sort | Zhang, Yi |
collection | PubMed |
description | Pyroptosis is a type of programmed cell death with an intense inflammatory response. Previous studies have shown that pyroptosis plays an important role in the pathogenesis and progression of lung cancer. However, the prognostic value and drug targets of pyroptosis-related lncRNAs in lung squamous cell carcinoma (LSCC) have never been studied. In the present study, we identified 1468 pyroptosis-related lncRNAs in LSCC by performing Pearson correlation analysis between the pyroptosis-related genes and the lncRNAs from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. The whole set was divided into a training and a test set with a 1:1 ratio. Univariate Cox regression and least absolute shrinkage and selection operator (LASSO) analyses were conducted to establish an 11 multilncRNA signature in the three sets. The signature divided LSCC patients into the low-risk and the high-risk groups. Kaplan–Meier analysis and receiver operating characteristic (ROC) indicated that the prognostic signature had a promising predictive capability for LSCC patients. Besides, the association of microenvironment and immunotherapy response with signature was also analyzed. Moreover, 28 potential compounds targeting signature were screened as possible drugs to treat LSCC. Finally, a nomogram model was constructed to offer the quantitative prediction and net benefit for the prognosis of LSCC patients. In conclusion, the 11 pyroptosis-related lncRNAs and their signature may be promising prognostic factors and therapeutic targets for patients with LSCC. |
format | Online Article Text |
id | pubmed-9249737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-92497372022-07-03 Identification of pyroptosis-related long non-coding RNAs with prognosis and therapy in lung squamous cell carcinoma Zhang, Yi Wang, Yuzhi Yin, Xiaoqing Huang, Yi Sci Rep Article Pyroptosis is a type of programmed cell death with an intense inflammatory response. Previous studies have shown that pyroptosis plays an important role in the pathogenesis and progression of lung cancer. However, the prognostic value and drug targets of pyroptosis-related lncRNAs in lung squamous cell carcinoma (LSCC) have never been studied. In the present study, we identified 1468 pyroptosis-related lncRNAs in LSCC by performing Pearson correlation analysis between the pyroptosis-related genes and the lncRNAs from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. The whole set was divided into a training and a test set with a 1:1 ratio. Univariate Cox regression and least absolute shrinkage and selection operator (LASSO) analyses were conducted to establish an 11 multilncRNA signature in the three sets. The signature divided LSCC patients into the low-risk and the high-risk groups. Kaplan–Meier analysis and receiver operating characteristic (ROC) indicated that the prognostic signature had a promising predictive capability for LSCC patients. Besides, the association of microenvironment and immunotherapy response with signature was also analyzed. Moreover, 28 potential compounds targeting signature were screened as possible drugs to treat LSCC. Finally, a nomogram model was constructed to offer the quantitative prediction and net benefit for the prognosis of LSCC patients. In conclusion, the 11 pyroptosis-related lncRNAs and their signature may be promising prognostic factors and therapeutic targets for patients with LSCC. Nature Publishing Group UK 2022-07-01 /pmc/articles/PMC9249737/ /pubmed/35778526 http://dx.doi.org/10.1038/s41598-022-15373-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhang, Yi Wang, Yuzhi Yin, Xiaoqing Huang, Yi Identification of pyroptosis-related long non-coding RNAs with prognosis and therapy in lung squamous cell carcinoma |
title | Identification of pyroptosis-related long non-coding RNAs with prognosis and therapy in lung squamous cell carcinoma |
title_full | Identification of pyroptosis-related long non-coding RNAs with prognosis and therapy in lung squamous cell carcinoma |
title_fullStr | Identification of pyroptosis-related long non-coding RNAs with prognosis and therapy in lung squamous cell carcinoma |
title_full_unstemmed | Identification of pyroptosis-related long non-coding RNAs with prognosis and therapy in lung squamous cell carcinoma |
title_short | Identification of pyroptosis-related long non-coding RNAs with prognosis and therapy in lung squamous cell carcinoma |
title_sort | identification of pyroptosis-related long non-coding rnas with prognosis and therapy in lung squamous cell carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249737/ https://www.ncbi.nlm.nih.gov/pubmed/35778526 http://dx.doi.org/10.1038/s41598-022-15373-6 |
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