T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During aging, T cells accumulate cholesterol, potentially affecting inflammation. However, the effect of cholesterol efflux pathways mediated by ATP-binding cassette A1 and G1 (ABCA1/ABCG1) on T cell-dependent age-rela...

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Detalles Bibliográficos
Autores principales: Bazioti, Venetia, La Rose, Anouk M., Maassen, Sjors, Bianchi, Frans, de Boer, Rinse, Halmos, Benedek, Dabral, Deepti, Guilbaud, Emma, Flohr-Svendsen, Arthur, Groenen, Anouk G., Marmolejo-Garza, Alejandro, Koster, Mirjam H., Kloosterhuis, Niels J., Havinga, Rick, Pranger, Alle T., Langelaar-Makkinje, Miriam, de Bruin, Alain, van de Sluis, Bart, Kohan, Alison B., Yvan-Charvet, Laurent, van den Bogaart, Geert, Westerterp, Marit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249754/
https://www.ncbi.nlm.nih.gov/pubmed/35778407
http://dx.doi.org/10.1038/s41467-022-31135-4

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