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Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining

DNA double-strand breaks (DSBs) threaten genomic stability, since their persistence can lead to loss of critical genetic information, chromosomal translocations or rearrangements, and cell death. DSBs can be repaired through the nonhomologous end-joining pathway (NHEJ), which processes and ligates D...

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Detalles Bibliográficos
Autores principales:	Kaminski, Andrea M., Chiruvella, Kishore K., Ramsden, Dale A., Bebenek, Katarzyna, Kunkel, Thomas A., Pedersen, Lars C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249759/ https://www.ncbi.nlm.nih.gov/pubmed/35778389 http://dx.doi.org/10.1038/s41467-022-31278-4

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