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Effective tumor cell abrogation via Venetoclax-mediated BCL-2 inhibition in KMT2A-rearranged acute B-lymphoblastic leukemia

Dysregulation of the intrinsic BCL-2 pathway-mediated apoptosis cascade is a common feature of hematological malignancies including acute B-lymphoblastic leukemia (B-ALL). The KMT2A-rearranged high-risk cytogenetic subtype is characterized by high expression of antiapoptotic protein BCL-2, likely du...

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Detalles Bibliográficos
Autores principales:	Richter, Anna, Lange, Sandra, Holz, Clemens, Brock, Luisa, Freitag, Thomas, Sekora, Anett, Knuebel, Gudrun, Krohn, Saskia, Schwarz, Rico, Hinz, Burkhard, Murua Escobar, Hugo, Junghanss, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249764/ https://www.ncbi.nlm.nih.gov/pubmed/35778418 http://dx.doi.org/10.1038/s41420-022-01093-3

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