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A conserved set of mutations for stabilizing soluble envelope protein dimers from dengue and Zika viruses to advance the development of subunit vaccines

Dengue viruses (DENV serotypes 1–4) and Zika virus (ZIKV) are related flaviviruses that continue to be a public health concern, infecting hundreds of millions of people annually. The traditional live-attenuated virus vaccine approach has been challenging for the four DENV serotypes because of the ne...

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Detalles Bibliográficos
Autores principales:	Phan, Thanh T.N., Hvasta, Matthew G., Kudlacek, Stephan T., Thiono, Devina J., Tripathy, Ashutosh, Nicely, Nathan I., de Silva, Aravinda M., Kuhlman, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249817/ https://www.ncbi.nlm.nih.gov/pubmed/35643320 http://dx.doi.org/10.1016/j.jbc.2022.102079

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