Cargando…

Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report

BACKGROUND: Hepatocellular carcinoma with neuroendocrine differentiation (HCC-NED) is a very rare subtype of primary liver cancer. Treatment allocation in these patients therefore remains a challenge. METHODS: We report the case of a 74-year-old man with a HCC-NED. The tumor was surgically removed i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meier, Marie-Anne, Nuciforo, Sandro, Coto-Llerena, Mairene, Gallon, John, Matter, Matthias S., Ercan, Caner, Vosbeck, Jürg, Terracciano, Luigi M., Soysal, Savas D., Boll, Daniel, Kollmar, Otto, Delaloye, Raphaël, Piscuoglio, Salvatore, Heim, Markus H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249908/ https://www.ncbi.nlm.nih.gov/pubmed/35789568 http://dx.doi.org/10.1038/s43856-022-00150-3

Ejemplares similares

Standardizing Patient-Derived Organoid Generation Workflow to Avoid Microbial Contamination From Colorectal Cancer Tissues
por: Marinucci, Mattia, et al.
Publicado: (2022)

Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report
por: Ercan, Caner, et al.
Publicado: (2022)

Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma
por: Gallon, John, et al.
Publicado: (2021)

The Role of Chronic Liver Diseases in the Emergence and Recurrence of Hepatocellular Carcinoma: An Omics Perspective
por: Zanotti, Sofia, et al.
Publicado: (2022)

Transcriptional Enhancer Factor Domain Family member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo‐Independent Regulation of Heat Shock Protein 70 Family Members
por: Coto‐Llerena, Mairene, et al.
Publicado: (2021)

Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis
por: Taha-Mehlitz, Stephanie, et al.
Publicado: (2021)

Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages
por: Ng, Charlotte K. Y., et al.
Publicado: (2022)

Circulating Cell-Free DNA Captures the Intratumor Heterogeneity in Multinodular Hepatocellular Carcinoma
por: Coto-Llerena, Mairene, et al.
Publicado: (2022)

High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes
por: Coto-Llerena, Mairene, et al.
Publicado: (2020)

Supervised learning based on tumor imaging and biopsy transcriptomics predicts response of hepatocellular carcinoma to transarterial chemoembolization
por: Boldanova, Tuyana, et al.
Publicado: (2021)

Arginine reprograms metabolism in liver cancer via RBM39
por: Mossmann, Dirk, et al.
Publicado: (2023)

Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors
por: Blumer, Tanja, et al.
Publicado: (2019)

Patient-derived organoids identify tailored therapeutic options and determinants of plasticity in sarcomatoid urothelial bladder cancer
por: Garioni, Michele, et al.
Publicado: (2023)

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies
por: Nuciforo, Sandro, et al.
Publicado: (2018)

YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis
por: Gao, Ruize, et al.
Publicado: (2021)

Organoids to model liver disease
por: Nuciforo, Sandro, et al.
Publicado: (2020)

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis
por: Simó-Riudalbas, Laia, et al.
Publicado: (2022)

USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis
por: Gao, Ruize, et al.
Publicado: (2021)

The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples
por: Stücheli, Simon, et al.
Publicado: (2022)

Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens
por: Srivatsa, Sumana, et al.
Publicado: (2022)

Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses
por: Chen, Qian, et al.
Publicado: (2021)

Malignant melanoma metastasis in the gallbladder. A case report of an unusual metastatic site
por: Hess, Gabriel Fridolin, et al.
Publicado: (2020)

Surgical Strategy Based on Radiological 3D Reconstruction in a Giant Metastatic Neuroendocrine Tumor of the Pancreas: A Case Report of an Interdisciplinary Approach
por: Hess, Gabriel Fridolin, et al.
Publicado: (2021)

Mechano-modulatory synthetic niches for liver organoid derivation
por: Sorrentino, Giovanni, et al.
Publicado: (2020)

GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers
por: Bianco, Gaia, et al.
Publicado: (2022)

Author Correction: GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers
por: Bianco, Gaia, et al.
Publicado: (2022)

Interferon lambda 4 can directly activate human CD19(+) B cells and CD8(+) T cells
por: Coto-Llerena, Mairene, et al.
Publicado: (2020)

Systematic identification of novel cancer genes through analysis of deep shRNA perturbation screens
por: Montazeri, Hesam, et al.
Publicado: (2021)

AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells
por: Pop, Oltin-Tiberiu, et al.
Publicado: (2023)

PD-L1 Expression in Triple-negative Breast Cancer—a Comparative Study of 3 Different Antibodies
por: Vlajnic, Tatjana, et al.
Publicado: (2022)

Cell Culture Replication of a Genotype 1b Hepatitis C Virus Isolate Cloned from a Patient Who Underwent Liver Transplantation
por: Koutsoudakis, George, et al.
Publicado: (2011)

Interplay between Basic Residues of Hepatitis C Virus Glycoprotein E2 with Viral Receptors, Neutralizing Antibodies and Lipoproteins
por: Koutsoudakis, George, et al.
Publicado: (2012)

Pregnancy at early age is associated with a reduction of progesterone-responsive cells and epithelial Wnt signaling in human breast tissue
por: Muenst, Simone, et al.
Publicado: (2017)

The short- and long-term outcome after the surgical management of common bile duct stones in a tertiary referral hospital
por: Hess, Gabriel F., et al.
Publicado: (2023)

Incidence of Liver Resection Following the Introduction of Caseload Requirements for Liver Surgery in Switzerland
por: Haak, Fabian, et al.
Publicado: (2022)

Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma
por: Dijkstra, Krijn K., et al.
Publicado: (2021)

Autofluorescence Imaging of Treatment Response in Neuroendocrine Tumor Organoids
por: Gillette, Amani A., et al.
Publicado: (2021)

Live slow-frozen human tumor tissues viable for 2D, 3D, ex vivo cultures and single-cell RNAseq
por: Restivo, Gaetana, et al.
Publicado: (2022)

High Density of CD16+ Tumor-Infiltrating Immune Cells in Recurrent Ovarian Cancer Is Associated with Enhanced Responsiveness to Chemotherapy and Prolonged Overall Survival
por: Lalos, Alexandros, et al.
Publicado: (2021)

Prevention of Hepatitis B Reactivation in Patients Receiving Immunosuppressive Therapy: a Case Series and Appraisal of Society Guidelines
por: Etienne, Samuel, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_l2enedvmujuqs216ingkeiqeel