Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability

BACKGROUND & AIMS: The expression and role of methyltransferase SET and MYND domain-containing protein 5 (SMYD5) in inflammatory bowel disease (IBD) is completely unknown. Here, we investigated the role and underlying mechanism of epithelial SMYD5 in IBD pathogenesis and progression. METHODS: Th...

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Detalles Bibliográficos
Autores principales: Hou, Yuning, Sun, Xiaonan, Gheinani, Pooneh Tavakoley, Guan, Xiaoqing, Sharma, Shaligram, Zhou, Yu, Jin, Chengliu, Yang, Zhe, Naren, Anjaparavanda P., Yin, Jun, Denning, Timothy L., Gewirtz, Andrew T., Liu, Yuan, Xie, Zhonglin, Li, Chunying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249919/
https://www.ncbi.nlm.nih.gov/pubmed/35643234
http://dx.doi.org/10.1016/j.jcmgh.2022.05.006

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